1. Plasma exudation and blood flow changes induced by intradermal injection of prostaglandins E2 (PGE2), I2 (PG12), D2 (PGD2) and F2 alpha (PGF2 alpha) were measured in rabbit dorsal skin by the use of [131I]-albumin and 133Xe. 2. Little plasma exudation was produced by any of the prostaglandins when injected alone. 3. Both PGE2 and PGI2 were potent at increasing blood flow, whereas PGF2 alpha and PGD2 produced an increase only at high doses. 4. All of the prostaglandins studied potentiated the plasma exudation induced by bradykinin. PGE2 and PGI2 had similar potent potentiating activity, whereas PGD2 and PGF2 alpha had activity at doses too high to be of biological significance. 5. Intradermal injections of arachidonate alone resulted in little plasma exudation but produced an increase in blood flow. Arachidonate potentiated bradykinin-induced plasma exudation. 6. Locally-injected indomethacin had no effect on basal blood flow and little effect on the exudation produced by bradykinin, but indomethacin did inhibit the vasodilatation and exudation potentiation produced by arachidonate. 7. PGE2 and PGI2 had similar potency in producing marked potentiation of plasma exudation induced by intradermal injection of zymosan. 8. In the ...Continue Reading
Comparison of the vasodepressor effects of prostacyclin and 6-oxo-prostaglandin F1alpha with those of prostaglandin E2 in rats and rabbits
The modulation of enhanced vascular permeability by prostaglandins through alterations in blood flow (hyperemia).
Potentiation of bradykinin-induced vascular permeability increase by prostaglandin E2 and arachidonic acid in rabbit skin
Cutaneous blood flow changes and weal induced by intradermal bradykinin following pretreatment with indomethacin and captopril
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Bradykinin-stimulated prostaglandin E2 production by endothelial cells and its modulation by antiinflammatory compounds
Activation of plasma kallikrein-kinin system and its significant role in pleural fluid accumulation of rat carrageenin-induced pleurisy
Comparative evaluation of arachidonic acid (AA)- and tetradecanoylphorbol acetate (TPA)-induced dermal inflammation
Modulation of mouse ear edema by cyclooxygenase and lipoxygenase inhibitors and other pharmacologic agents
Influence of a diet rich in eicosapentaenoic acid on the development of rat paw oedema and on the formation of prostaglandins I2 and E2.
Characterization of a polyacrylamide gel-induced granuloma in mice: involvement of arachidonate metabolites
Polymorphonuclear leucocyte accumulation in inflammatory dermal sites measured by a novel neutrophil specific marker protein
Exacerbation of inflammatory bowel diseases associated with the use of nonsteroidal anti-inflammatory drugs: myth or reality?
Ameliorative effect of p-coumaric acid, a common dietary phenol, on adjuvant-induced arthritis in rats.
Cyclooxygenase-dependent signaling is causally linked to non-melanoma skin carcinogenesis: pharmacological, genetic, and clinical evidence
Mechanism of ionophore A23187 induction of plasma protein leakage and of its inhibition by indomethacin
Big endothelin-1 and big endothelin-3 are constrictor agents in the microvasculature: evidence for the local phosphoramidon-sensitive conversion of big endothelin-1
Effect of chronic nitric oxide synthesis inhibition on the inflammatory responses induced by carrageenin in rats
Phoneutria nigriventer (armed spider) venom induces increased vascular permeability in rat and rabbit skin in vivo
Activation of tissue kallikrein-kininogen-kinin system in rabbit skin by a fraction isolated from Phoneutria nigriventer (armed spider) venom
Isolation of a polypeptide from Phoneutria nigriventer spider venom responsible for the increased vascular permeability in rabbit skin
Estrogen induced changes in uterine sensitivity for the decidual cell reaction: interactions between prostaglandin E2 and histamine or bradykinin
Changes in the levels of prostaglandins and thromboxane and their roles in the accumulation of exudate in rat carrageenin-induced pleurisy--a profile analysis using gas chromatography-mass spectrometry
Characterization of the EP-receptor mediating dilatation and potentiation of inflammation in rabbit skin
Effect of nonsteroidal anti-inflammatory agents on immune complex- and chemotactic factor-induced inflammation
Comparison of the effects of glucocorticoid and indomethacin treatment on the acute inflammatory reaction in rabbits
Prompt elevations of PGE2 and thromboxane A2 metabolites in peripheral node efferent lymph of sheep following drainage area immunization.
C5a and antigen-induced tracheal contraction: effect of a combination of an antihistamine and cyclo-oxygenase inhibitors
Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.