Prostaglandin E2/EP1 signaling pathway enhances intercellular adhesion molecule 1 (ICAM-1) expression and cell motility in oral cancer cells.

The Journal of Biological Chemistry
Shun-Fa YangChih-Hsin Tang

Abstract

Oral squamous cell carcinoma has a striking tendency to migrate and metastasize. Cyclooxygenase (COX)-2, the inducible isoform of prostaglandin (PG) synthase, has been implicated in tumor metastasis. However, the effects of COX-2 on human oral cancer cells are largely unknown. We found that overexpression of COX-2 or exogenous PGE(2) increased migration and intercellular adhesion molecule 1 (ICAM)-1 expression in human oral cancer cells. Using pharmacological inhibitors, activators, and genetic inhibition of EP receptors, we discovered that the EP1 receptor, but not other PGE receptors, is involved in PGE(2)-mediated cell migration and ICAM-1 expression. PGE(2)-mediated migration and ICAM-1 up-regulation were attenuated by inhibitors of protein kinase C (PKC)δ, and c-Src. Activation of the PKCδ, c-Src, and AP-1 signaling pathway occurred after PGE(2) treatment. PGE(2)-induced expression of ICAM-1 and migration activity were inhibited by a specific inhibitor, siRNA, and mutants of PKCδ, c-Src, and AP-1. In addition, migration-prone sublines demonstrated that cells with increased migration ability had higher expression of COX-2 and ICAM-1. Taken together, these results indicate that the PGE(2) and EP1 interaction enhanced migrati...Continue Reading

References

Jan 1, 1996·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·A van de Stolpe, P T van der Saag
Apr 1, 1998·Journal of the National Cancer Institute·D HwangE Levine
Aug 31, 2000·Annual Review of Biochemistry·W L SmithR M Garavito
Jul 31, 2001·International Journal of Cancer. Journal International Du Cancer·J G RozicP K Lala
Aug 15, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·M LeitgesM Huber
Jan 25, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·G J Thomas, P M Speight
Jan 31, 2002·Annual Review of Medicine·Marco E Turini, Raymond N DuBois
Sep 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Li MaJohn L Wallace
Nov 16, 2002·Prostaglandins & Other Lipid Mediators·Ikuo Morita
May 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kristen PageSvetlana Iasvoyskaia
May 1, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Timothy D Warner, Jane A Mitchell
Mar 19, 2005·Carcinogenesis·Caridad RosetteMikhail F Denissenko
Apr 23, 2005·Biochemical and Biophysical Research Communications·Robert Roskoski
Jul 19, 2005·Molecular and Cellular Biology·Wei-Chien Huang, Ching-Chow Chen
May 10, 2006·RNA·Yuriy FedorovAnastasia Khvorova
Oct 19, 2006·Cancer Research·Amy M FultonNamita Kundu
Nov 18, 2006·Cell·Gaorav P Gupta, Joan Massagué
Jul 24, 2007·International Journal of Oral and Maxillofacial Surgery·A J Lyons, J Jones
Apr 17, 2008·Cancer Research·Alakananda BasuChandreyi Basu
Sep 11, 2008·Current Pharmaceutical Design·Tahl Zimmerman, Francisco J Blanco
Dec 3, 2008·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·H TokudaO Kozawa
Mar 25, 2009·Pharmacological Reports : PR·Charlotte Lawson, Sabine Wolf
Apr 1, 2009·Journal of Cellular Physiology·Jing-Yuan ChuangChih-Hsin Tang
Nov 17, 2009·Cancer Investigation·Nektaria MakriliaKostas Syrigos
Dec 24, 2009·Nature Reviews. Cancer·Jay S Desgrosellier, David A Cheresh

❮ Previous
Next ❯

Citations

Nov 4, 2011·Cancer Metastasis Reviews·Andrea CombaMarìa Eugenia Pasqualini
Oct 18, 2011·Cancer Metastasis Reviews·Claus Schneider, Ambra Pozzi
Feb 22, 2012·Carcinogenesis·Po-Chun ChenChih-Hsin Tang
Jan 20, 2012·Reproductive Biology and Endocrinology : RB&E·Chellakkan S BlessonLena Sahlin
Feb 8, 2013·Cell & Bioscience·Viola AllajDaotai Nie
Jan 9, 2014·International Journal of Molecular Sciences·Jing-Yuan ChuangChih-Hsin Tang
Sep 13, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Chi-Ming WuChih-Hsin Tang
May 19, 2011·Journal of Cancer Research and Clinical Oncology·Christine SchröderKarin Milde-Langosch
Jul 6, 2014·International Journal of Molecular Sciences·Chi-Ting HorngChih-Hsin Tang
Feb 9, 2016·Seminars in Cancer Biology·Nagendra Sastry YarlaGovinda Rao Duddukuri
Sep 18, 2015·British Journal of Pharmacology·G O'Callaghan, A Houston
May 23, 2015·Cancer Biology & Therapy·Smrithi RajendiranJamboor K Vishwanatha
Jul 13, 2013·Biochimica Et Biophysica Acta·Tien-Huang LinChih-Hsin Tang
May 13, 2014·The International Journal of Biochemistry & Cell Biology·Tsai-Hsien HungKowit Yu Chong
Jan 3, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ming-Hsien ChienShun-Fa Yang
Mar 28, 2017·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Xiaohui LiWeizhong Li
Jun 28, 2013·International Journal of Molecular Sciences·Hsin-Shan YuChih-Hsin Tang
Aug 29, 2018·British Journal of Pharmacology·Debashree BasudharDavid A Wink
Mar 4, 2020·International Journal of Molecular Sciences·Gabriel Leonardo MagrinReinhard Gruber
Sep 27, 2018·Cancers·Walaa Hamed Shaker NasryChelsea K Martin
Jul 5, 2018·Cancer Metastasis Reviews·Wanyeon KimBuHyun Youn
Dec 29, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Maria Teresa Rizzo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.