Prostaglandin-endoperoxide H synthase-2 expression and activity increases with term labor in human chorion

The American Journal of Physiology
J E MijovicD M Olson

Abstract

We investigated the changes in prostaglandin-endoperoxide H synthase (PGHS) specific activity and the levels and distribution of PGHS-1 and PGHS-2 mRNA in chorion collected at term before the onset of labor (CS) and after term labor and delivery (SL). PGHS specific activity and PGHS-2 mRNA abundance were higher in chorion collected after SL compared with that obtained at CS (P < 0.001); there was no difference in the levels of PGHS-1 mRNA between CS and SI, tissues. The increase in PGHS specific activity at SL was significantly correlated with PGHS-2 mRNA expression (P < 0.05) but not with PGHS-1 mRNA levels. In situ hybridization indicated that the pervasiveness of staining for PGHS-1 mRNA throughout full-thickness membranes did not change with labor onset; however, a greater number of cells expressed PGHS-2 in SL tissues. Our results demonstrate a selective increase in PGHS-2 expression and activity in chorion trophoblasts and mesenchymal cells with term labor onset. These observations are similar to those concerning amnion and imply that a concerted mechanism may exist in the fetal membranes to induce PGHS-2 expression at labor.

References

Feb 1, 1976·British Journal of Obstetrics and Gynaecology·M J Keirse, A C Turnbull
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T Hla, K Neilson
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Feb 1, 1994·Canadian Journal of Physiology and Pharmacology·B AlnaifW Gibb

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Citations

Jul 11, 2002·American Journal of Physiology. Cell Physiology·Laura Koumas, Richard P Phipps
Jan 22, 2019·Canadian Journal of Physiology and Pharmacology·Daniela UrregoDonna M Slater

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