Prostaglandin endoperoxide synthase 2 (PTGS2) and prostaglandins F2α and E2 synthases (PGFS and PGES) expression and prostaglandin F2α and E2 secretion following oestrogen and/or progesterone stimulation of the feline endometrium

Reproduction in Domestic Animals = Zuchthygiene
M J SiemieniuchD J Skarzynski

Abstract

Sex steroids in synergy with prostaglandins (PG) are involved in the regulation of cyclic ovarian function. In this study, we investigated the mRNA expression of three genes involved in arachidonic acid (AA) metabolism and hence PG production in domestic cats: PG-endoperoxide synthase (PTGS2), PGF(2α) synthase (PGFS) and PGE(2) synthase (PGES). Feline endometria (n = 16) were collected at oestrus and mid and late phases of pseudopregnancy. In addition, the effects of E(2) and/or P(4) on PG secretion and gene expression on endometrial explants were studied in an in vitro culture system. Expression levels of all examined genes were up-regulated at the mid phase of pseudopregnancy. The effects of E(2) and/or P(4) treatment on both PG secretion and expression of the genes were observed after 12 h of culture. Expression of PGES was significantly up-regulated by E(2) plus P(4) at oestrus and the mid phase of pseudopregnancy and was also up-regulated by a single treatment with P(4) at late pseudopregnancy (p < 0.05). Simultaneous incubation with E(2) and P(4) up-regulated PTGS2 gene expression at oestrus and mid-luteal phase (p < 0.05). Progesterone plus E(2) significantly increased PGE(2) secretion at oestrus and the mid phase of pse...Continue Reading

References

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Nov 26, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Mariusz Pawel KowalewskiBernd Hoffmann
Mar 26, 2010·Animal Reproduction Science·Marta J SiemieniuchKiyoshi Okuda

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Citations

Mar 25, 2014·Mediators of Inflammation·Marta J SiemieniuchMariusz P Kowalewski
Jun 12, 2016·Reproductive Biology·Ewelina Jursza-Piotrowska, Marta J Siemieniuch
Dec 3, 2014·Reproductive Biology·Ewelina JurszaMarta J Siemieniuch
May 26, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Lina ZschockeltBeate C Braun

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