Prostaglandin F2α: a bone remodeling mediator

Journal of Cellular Physiology
Dimitrios AgasMaria G Sabbieti

Abstract

Prostaglandin F2α (PGF2α) plays multiple roles on bone metabolism by regulating a wide range of signaling pathways. PGF2α, via activation of PKC, stimulates Na-dependent inorganic phosphate (Pi) transport system in osteoblasts; up-regulates interleukin (IL)-6 synthesis; increases vascular endothelial growth factor (VEGF). In addition, PGF2α acts as a strong mitogenic and survival agent on osteoblasts, and these effects are, at least in part, mediated by the binding of fibroblast growth factor-2 (FGF-2) to the specific receptor FGFR1. The understanding of PGF2α intracellular network, albeit complex to clarify, provides molecular bases useful to identify the players of osteoblast proliferation, apoptosis, and the associated angiogenic processes. Indeed, the molecular mechanism that underline PGF2α-regulated bone metabolism may be a promising platform for the development of novel targeted therapies in the treatment of bone disorders and disease.

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Citations

Nov 30, 2012·Archives of Toxicology·Dimitrios AgasLuigi Marchetti
Apr 4, 2015·Clinical Reviews in Bone and Mineral Metabolism·Janalee Isaacson, Marco Brotto
Apr 6, 2013·Journal of Cellular Physiology·Dimitrios AgasMarja M Hurley
Apr 15, 2016·Nutrients·Kevin B HadleyNorman Salem
Jan 8, 2015·Cytokine & Growth Factor Reviews·Dimitrios AgasMaria Giovanna Sabbieti
Feb 26, 2015·Advances in Wound Care·Lauren Alexis HoeferlinDayanjan Shanaka Wijesinghe
Dec 24, 2017·Photochemistry and Photobiology·Viviane JettarAguinaldo S Garcez
Oct 9, 2014·Journal of Cellular Physiology·Thomas L McCarthy, Michael Centrella
Sep 21, 2013·American Journal of Physiology. Endocrinology and Metabolism·Dimitrios AgasMaria Giovanna Sabbieti
Jan 9, 2016·International Journal of Molecular Medicine·Gen KuroyanagiHaruhiko Tokuda
Oct 19, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Saja BaraghithyJoseph Tam
Jan 23, 2021·Journal of Orthopaedic Surgery and Research·Gen KuroyanagiHaruhiko Tokuda
Nov 27, 2020·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Andressa Cristina Antunes SantosRicardo Ambrosio Fock

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