Prostaglandin gel versus oxytocin - prelabour rupture of membranes at term - A randomised controlled trial

The Australian & New Zealand Journal of Obstetrics & Gynaecology
Kassam MahomedChristopher R Weekes

Abstract

Pre-labour rupture of membranes (PROM) at term is a common event with early induction of labour reducing infectious morbidity without increasing the caesarean rate. Syntocinon is commonly used for induction but prostaglandins are also routinely used. Large studies have shown no difference in the maternal and neonatal outcomes with either method. To assess the safety and efficacy of vaginal prostaglandin (PG) compared to syntocinon for induction of labour in term-PROM. This was a single-centre randomised controlled trial at Ipswich Hospital of women presenting at ≥37 weeks gestation with PROM. Women were randomised and managed in labour as per local guidelines. Analysis was by intention to treat. One hundred and eighty-four women were recruited, 90 in the PG group and 94 in the oxytocin group. Women in both arms were of similar demographics and 53% of women in the PG group did not require any oxytocin. There was a statistically significant lower incidence of fetal heart rate abnormality in the PG group, 4.4% versus 12.8%. There was no difference in epidural use, caesarean section, maternal infection, admission to special care nursery or neonatal sepsis. Time to onset of labour was significantly longer in the PG group, 25.7 h ver...Continue Reading

References

Jun 1, 1997·Obstetrics and Gynecology·E L Mozurkewich, F M Wolf
May 15, 2010·Taiwanese Journal of Obstetrics & Gynecology·Cigdem KuntLeyla Mollamahmutoglu
Nov 3, 2010·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Christopher R Weekes, Kassam Mahomed
Sep 20, 2011·American Journal of Obstetrics and Gynecology·Kemal GüngördükAhmet Sahbaz
Apr 30, 2014·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Ekaterina MishaninaCatherine Meads
May 24, 2015·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Dean LeducBarbara Parish
Jun 30, 2015·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Yan ZhangLirong Ren

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Citations

Nov 2, 2019·Gynécologie, Obstétrique, Fertilité & Sénologie·A Girault

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