Prostaglandin H synthase and xenobiotic oxidation

Annual Review of Pharmacology and Toxicology
T E ElingM F Hughes

Abstract

We have attempted in this article to summarize and review cooxidation reactions that occur during the metabolism of AA and potential roles that these reactions can play in the activation and detoxification of chemicals. This review summarizes approximately 15 years of intensive investigation by a number of laboratories, and as such not all studies are cited, and in some cases data are not discussed with the emphasis that the original investigators may have intended. The major focus of many of these studies has been toward carcinogenesis. In the future, emphasis may shift to the formation of metabolites that will lead to other toxic effects. The cooxidation reactions that occur during AA metabolism are dependent upon the peroxidase activity of PHS. For some chemicals that are not cosubstrates, the epoxidation reactions that occur are dependent upon the subsequent formation of peroxyl radicals. A large and diverse number of chemicals are metabolized by an equally large and diverse number of chemical reactions. The unifying theme is the free radical nature of these oxidations. The subsequent reactions that these chemicals undergo is dictated by the nature of the free radical and the environment in which it is generated. Ample evid...Continue Reading

Citations

Dec 1, 1994·Cancer Metastasis Reviews·L J Marnett
Jul 13, 2000·European Journal of Drug Metabolism and Pharmacokinetics·H Vainio, G Morgan
Nov 13, 2001·British Journal of Pharmacology·Y S Bakhle
Mar 26, 2002·Journal of Toxicology and Environmental Health. Part a·I-Ching Ho, Te-Chang Lee
Aug 10, 2007·Journal of Toxicology and Environmental Health. Part a·Lee A FrederickCharles D Rice
Jan 12, 2010·Human Reproduction Update·Marleen M H J van GelderNel Roeleveld
May 25, 1999·Protein Science : a Publication of the Protein Society·A M Dean, F M Dean
Jan 25, 2002·Annual Review of Pharmacology and Toxicology·Lawrence J Marnett, Raymond N DuBois
Oct 1, 1994·Environmental Health Perspectives·D Malejka-Giganti, C L Ritter
Nov 28, 2006·Expert Opinion on Drug Metabolism & Toxicology·Margherita Strolin BenedettiEugène Baltes
May 1, 1996·Critical Reviews in Toxicology·W Dekant, S Vamvakas
Aug 1, 1996·Drug and Chemical Toxicology·D B Couch
May 29, 2010·Pharmacological Reports : PR·Nilanjan GhoshSubhash C Mandal
Nov 30, 2011·Best Practice & Research. Clinical Gastroenterology·Karsten Schrör
Nov 29, 2005·International Journal of Experimental Pathology·Giovana R ThomasJacinto Regalado
Mar 21, 2007·Chemistry & Biodiversity·Bernard Testa, Stefanie D Krämer
Jun 8, 2011·Basic & Clinical Pharmacology & Toxicology·Cristina Bichels HebedaSandra Helena Poliselli Farsky
Sep 9, 2010·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Matthew R ClutterGarry P Nolan
Feb 1, 1991·Research Communications in Chemical Pathology and Pharmacology·A K Naidu, A P Kulkarni
Dec 14, 2006·Prostaglandins & Other Lipid Mediators·Ying Yu, Colin D Funk
Aug 1, 1997·Hematology/oncology Clinics of North America·M J Kahn, D G Morrison
Oct 25, 2013·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Marie StiborováHeinz H Schmeiser
Feb 26, 2000·BJU International·A F Badawi
Aug 3, 2011·Toxicology and Applied Pharmacology·Aurélia Del BufaloBernard Pipy
Apr 24, 1991·Biochimica Et Biophysica Acta·W L Smith, L J Marnett

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.