Prostaglandin I2 half-life regulated by high density lipoprotein is decreased in acute myocardial infarction and unstable angina pectoris

Circulation
T AoyamaC Kawai

Abstract

To investigate the prostaglandin I2 (PGI2) half-life regulated by high density lipoprotein (HDL) in patients with coronary artery disease (CAD), we determined the stability of PGI2 and serum apolipoprotein A-I (Apo A-I) and apolipoprotein A-II (Apo A-II) levels in four age-matched groups of patients: controls (n = 17), angina pectoris (n = 18), unstable angina pectoris (n = 17), myocardial infarction (n = 19) (acute phase, 3.6 +/- 1.7 hours from onset; subacute phase, 75 +/- 15 hours from onset in the same patients). Serum PGI2 half-life and total serum Apo A-I levels were lower in the CAD group than in the control group. PGI2 was least stable in patients with unstable angina and the acute phase of myocardial infarction. In these patients, the molar ratio of Apo A-I to Apo A-II and HDL-associated Apo A-I levels were decreased, and free Apo A-I levels were increased. After in vitro incubation of HDL with increasing amounts of Apo A-II, Apo A-I in HDL was displaced by Apo A-II, with the parallel decrease in stability of PGI2. Free Apo A-I cannot stabilize PGI2. HDL-associated Apo A-I, whose amount is affected by Apo A-II, stabilized PGI2 and correlated well with stability of PGI2 in patients with CAD and control patients. Decreas...Continue Reading

References

Jun 1, 1978·European Journal of Clinical Investigation·T IshikawaN E Miller
Jul 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·K B Pomerantz, D P Hajjar
Nov 1, 1987·Atherosclerosis·P PuchoisJ C Fruchart
Oct 9, 1986·The New England Journal of Medicine·C T ShermanL Morgenstern
Oct 16, 1986·The New England Journal of Medicine·D J FitzgeraldG A FitzGerald
Nov 26, 1987·The New England Journal of Medicine·J B KruskalR E Kirsch
Jan 1, 1985·The Journal of Clinical Investigation·K K WuA C Papp
Aug 1, 1985·Journal of the American College of Cardiology·D R BresnahanH C Smith
Feb 25, 1972·Biochemical and Biophysical Research Communications·C J FieldingP E Fielding
Dec 1, 1984·Prostaglandins, Leukotrienes, and Medicine·Y YuiC Kawai
Aug 18, 1983·The New England Journal of Medicine·J J MaciejkoS J Mao
Feb 27, 1984·The American Journal of Medicine·W P Castelli
May 1, 1982·Metabolism: Clinical and Experimental·F C BallantyneD Ballantyne
Aug 1, 1982·The American Journal of Cardiology·Y YuiT Murakami
Jun 24, 1982·The New England Journal of Medicine·R A NorumP Alaupovic
Jul 1, 1981·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·G FagerG Bondjers
Sep 1, 1955·The Journal of Clinical Investigation·R J HAVELJ H BRAGDON

❮ Previous
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Citations

Dec 1, 1992·Clinical Cardiology·F E KuhnC E Rackley
Nov 1, 1996·Clinical Cardiology·L E Rabbani, E M Antman
Jan 15, 1996·Thrombosis Research·C PirichH Sinzinger
Jan 1, 1994·Pharmacology & Therapeutics·G FranceschiniL Calabresi
Jan 1, 1995·Pharmacology & Therapeutics·C R Sirtori
Dec 4, 2003·Atherosclerosis·Robert S Rosenson
Mar 11, 2000·Disease-a-month : DM·P R Liebson, E A Amsterdam
Mar 8, 2002·Atherosclerosis·Jerzy-Roch NoferArnold von Eckardstein
Dec 23, 1998·Atherosclerosis·R S Rosenson, G D Lowe
Oct 23, 1997·Thrombosis Research·C PirichH Sinzinger
Feb 12, 1998·International Journal of Cardiology·A de Padua MansurJ A Ramires
Jan 1, 1994·Journal of Internal Medicine·O P HeinonenM H Frick
Jul 1, 1995·Pharmacology & Toxicology·R J Gryglewski
May 8, 2010·American Journal of Respiratory and Critical Care Medicine·Gustavo A HeresiRaed A Dweik
Aug 10, 2000·Drugs·P H Chong, B S Bachenheimer
Jun 1, 1995·Annals of Medicine·R J Gryglewski
Aug 1, 1994·Disease-a-month : DM·R S RosensonC C Tangney
Feb 29, 2008·Critical Reviews in Oncology/hematology·Jay M LeeSteven M Dubinett
Dec 1, 1991·The American Journal of Cardiology·F E KuhnC E Rackley
Dec 15, 1991·Thrombosis Research·L L LongeneckerG L Longenecker
Jun 14, 2016·The American Journal of Cardiology·Carolyn M LarsenGarvan C Kane
Sep 9, 2017·Oncotarget·Aurélie HautefortFrédéric Perros
Jul 9, 2020·Pharmacology & Therapeutics·Jane A MitchellTimothy D Warner
May 18, 2021·Pulmonary Circulation·Ghaleb KhirfanGustavo A Heresi
Sep 27, 1996·Atherosclerosis·V MustadP M Kris-Etherton

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