PMID: 11904606Mar 21, 2002Paper

Prostaglandin-induced activation of uterine contractility in pregnant rats does not involve potassium channels

American Journal of Obstetrics and Gynecology
Carolyn A l BailieRobert E Garfield

Abstract

The uterus is a target for prostaglandins, especially at the end of gestation. Whether potassium channels are involved in the effect of prostaglandins is not clear. The aim of this study was to find out. Concentration-response relationships to prostaglandins (prostaglandin F2alpha, prostaglandin E2, and prostaglandin I2 [carbacyclin]; 10(-10) mol/L-10(-4) mol/L) were studied in isolated uterine rings from mid pregnancy (day 14) and late pregnancy (day 21) rats (Krebs solution, 5% CO2 in air, 37 degrees C; pH, 7.4). Rings were incubated for 30 minutes with either solvent or adenosine triphosphate-sensitive potassium channel inhibitor or opener glibenclamide and levcromakalim or with calcium-sensitive potassium channel inhibitor or opener NS1619 and iberiotoxin, respectively. The changes in integral activity were compared after each concentration of the agent and were expressed as a percent of the basal integral activity. The increases in spontaneous contractile activity induced by prostaglandin E2 and carbacyclin, but not prostaglandin F2alpha, were statistically significantly higher in tissues from late pregnancy versus mid pregnancy rats and were not affected by any of the K-channel openers or inhibitors. Adenosine triphosphat...Continue Reading

References

Dec 1, 1992·Naunyn-Schmiedeberg's Archives of Pharmacology·T YamagishiN Taira
Jul 24, 1998·Annals of Medicine·W Gibb
Sep 16, 1999·American Journal of Obstetrics and Gynecology·T OkawaR E Garfield
Apr 14, 2000·American Journal of Obstetrics and Gynecology·T OkawaR E Garfield

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Citations

Jun 29, 2007·Seminars in Cell & Developmental Biology·Adam M BrainardSarah K England
Apr 28, 2012·Reproductive Sciences·Mrinalini BalkiJose C A Carvalho
Dec 19, 2020·Acta Physiologica·Manasi MalikSarah K England

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