PMID: 2115739Jul 1, 1990Paper

Prostaglandin influences on afferent arteriolar responses to vasoconstrictor agonists

The American Journal of Physiology
E W InschoL G Navar

Abstract

The present study was designed to evaluate, at the microvascular level, the ability of prostaglandins E2 (PGE2) and I2 (PGI2) to counteract the afferent vasoconstrictor effects of angiotensin II (ANG II) and norepinephrine (NE). The renal microvasculature of rats pretreated with captopril and indomethacin was studied directly by use of the in vitro blood-perfused juxtamedullary nephron technique combined with videomicroscopy. Afferent arterioles averaged 22.7 +/- 0.6 microns ID (n = 59) under control conditions. Topical administration of PGE2 revealed a concentration-dependent afferent vasoconstriction, whereas PGI2 (10(-7) to 10(-5) M) failed to significantly alter afferent arteriolar diameter. Afferent arterioles constricted during exposure to either 10(-9) M ANG II (-15 +/- 3%, n = 13) or 10(-7) M NE (-19 +/- 3%, n = 13). Addition of PGE2 (10(-6) M) to the bathing solution enhanced the vasoconstrictor influences of ANG II and NE by an additional 18 +/- 6 and 13 +/- 4%, respectively. In contrast, while 10(-6) M PGI2 had no effect on ANG II-induced afferent vasoconstriction, it did produce a 30% attenuation of NE-induced constriction. Furthermore, pretreatment of the tissue with 10(-6) M PGI2 prevented development of NE-induce...Continue Reading

Citations

Dec 7, 2006·American Journal of Physiology. Renal Physiology·William F van RodijnenGeert-Jan Tangelder
Jan 11, 2007·American Journal of Physiology. Renal Physiology·Markus P SchneiderDavid M Pollock
Oct 11, 2001·American Journal of Physiology. Renal Physiology·M T LlinásF J Salazar
Jan 20, 2007·Experimental Physiology·Kesavarao Kumar EbenezarFrancine Gabriel Smith
Sep 21, 2000·American Journal of Physiology. Renal Physiology·K E Purdy, W J Arendshorst
Feb 22, 2001·Annual Review of Physiology·M D Breyer, R M Breyer
Aug 9, 2002·American Journal of Physiology. Renal Physiology·John D ImigRichard M Breyer
Jan 18, 2006·Acta Pharmacologica Sinica·Chun-guang Chen, Yi-ping Wang
Jan 16, 2009·American Journal of Physiology. Renal Physiology·Magali Araujo, William J Welch
Jan 31, 2020·Physiological Reviews·Jens Leipziger, Helle Praetorius
Jul 15, 2000·American Journal of Physiology. Renal Physiology·M D Breyer, R M Breyer
Nov 30, 2000·American Journal of Physiology. Renal Physiology·J D Imig
Jul 22, 2018·Pflügers Archiv : European journal of physiology·Manuel MeurerKlaus Höcherl

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