Prostaglandin involvement in contractions evoked in rabbit detrusor by field stimulation and by adenosine 5'-triphosphate

Canadian Journal of Physiology and Pharmacology
J W Downie, C Larsson

Abstract

Previous reports suggest that in rabbit urinary bladder both noncholinergic nonadrenergic excitatory responses and the contraction produced by adenosine 5'-triphosphate (ATP) are antagonized by indomethacin. We have attempted by further indirect testing on isolated detrusor strips to determine what role prostaglandins (PGs) might play in these processes. The second part of the biphasic contractile response to ATP was reduced to about 30% of control by PG synthesis inhibitors but the initial phase of the ATP response and te contraction produced by the beta, gamma-methylene analogue of ATP were unaffected. At concentrations that did not affect the response to acetylcholine but greatly suppressed the response to arachidonic acid, indomethacin antagonized the contraction evoked by field stimulation by about 30% at 1-2 Hz (largely noncholinergic and nonadrenergic). SC 19220, a putative PG receptor blocker, also produced about 25% reduction in the response to field stimulation but with only about 50% reduction in the response to arachidonic acid, PGE2, or PGF2alpha, SC 19220 also antagonized the frequency-response curve in atropine-treated strips. These findings lead us to suggest that beside maintaining tone and spontaneous activity...Continue Reading

Citations

Jan 26, 2010·The Journal of Urology·Mohammad Sajjad Rahnama'iJames I Gillespie
Mar 14, 2012·Nature Reviews. Urology·Mohammad S Rahnama'iGommert A van Koeveringe
Oct 11, 2017·Annual Review of Pharmacology and Toxicology·Sang Don KohKenton M Sanders
Dec 19, 2013·Nephro-urology Monthly·Mohammad Sajjad Rahnama'iPhilip E Van Kerrebroeck
Nov 23, 2013·Purinergic Signalling·Geoffrey Burnstock

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