PMID: 6969698Nov 1, 1980Paper

Prostaglandin levels and lysosomal enzyme activities in irradiated rats

International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
P J Trocha, G N Catravas

Abstract

Whole-body irradiation of rats results in the release of hydrolases from lysosomes, an increase in lysosomal enzyme activities, and changes in the prostaglandin levels in spleen and liver tissues. A transient increase in the concentration of prostaglandins E and F and leakage of lysosomal hydrolases occurred in both spleen and liver tissues 3-6 hours after the animals were irradiated. Maximal values for hydrolase activities, prostaglandin E and F content, and release of lysosomal enzymes were found 4 days postirradiation in rat spleens whereas in the liver only slight increases were observed at this time period for prostaglandin F levels. On day 7 there was a final rise in the spleen's prostaglandin E and F concentrations and leakage of hydrolases from the lysosomes before returning to near normal values on day 11. The prostaglandin F concentration in liver was also slightly elevated on the 7th day after irradiation and then decreased to control levels.

Citations

Feb 1, 1989·International Journal of Radiation Biology·M SchwenenW Schröder
Nov 1, 1982·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·L K Steel, G N Catravas
Aug 12, 2010·International Journal of Radiation Biology·Mona A El-GhazalyMohamed T Khayyal
Oct 22, 2011·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Undurti N Das
Dec 13, 2016·Canadian Journal of Physiology and Pharmacology·M A El-GhazalyS A Kenawy

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