Prostaglandin oligomeric derivatives inhibit in vitro formation of dehydrated cells from sickle red cells.

Prostaglandins, Leukotrienes, and Essential Fatty Acids
S T Ohnishi, M Katsuoka

Abstract

Two types of oligomeric derivatives of prostaglandin E1 were synthesized, a free-acid type and a lipophilic ester type. Neither compound inhibited sickling of red blood cells from sickle cell anaemia patients. However, both were found to inhibit the in vitro formation of dehydrated, dense cells (DC) caused by repeated cycles of sickling and unsickling of sickle cells. Both inhibited the formation of DC in a dose-related manner, but the ester type compound was more effective than the acid-type compound. Concentrations at which these compounds inhibit the DC formation by 50% were 5.2 microM and 40 microM for ester and free-acid compounds, respectively. A possible inhibition mechanism is discussed.

References

Sep 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J HofrichterW A Eaton
Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·B D PolisS Kwong
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May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·T AsakuraE Schwartz
Nov 25, 1949·Science·L PAULING, H A ITANO

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Citations

Apr 1, 1993·Journal of Anesthesia·A SakamotoR Ogawa
Mar 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S T OhnishiR Ogawa
Apr 1, 1989·Cell Biochemistry and Function·S T OhnishiM Katsuoka
Jan 1, 1993·The American Journal of Emergency Medicine·T SaitoR Ogawa

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