Prostaglandin production by cultured cynomolgus monkey trabecular meshwork cells

Prostaglandins, Leukotrienes, and Essential Fatty Acids
R N Weinreb, M D Mitchell

Abstract

Monkey trabecular meshwork (MTM) cells synthesize a variety of prostaglandins, including large amounts of prostaglandin E2 (PGE2) and smaller amounts of 6-keto-PGF1 alpha and PGF2 alpha. The predominance of PGE2 production by the MTM cells is similar to that observed in human trabecular meshwork cells. In contrast, the relative amounts of 6-keto-PGF1 alpha and PGF2 alpha were reversed compared with the human cells. The MTM cells produced increased amounts of PGE2 in response to treatment with bradykinin, platelet activating factor, and A-23187. Dexamethasone caused a dose-dependent inhibition of PGE2 production with 50% inhibition by 10(-8) M, although this response was variable.

References

Feb 29, 1988·Biochemical and Biophysical Research Communications·M D MitchellL Varticovski
Jan 1, 1985·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·G Giuffrè

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Citations

Sep 3, 2002·Survey of Ophthalmology·Robert N WeinrebPaul L Kaufman
Apr 23, 2008·International Ophthalmology Clinics·Thomas D PatrianakosDavid S Walton

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