Abstract
Prostaglandins are potent mediators of the inflammatory response and are also involved in cancer development. In this study, we show that human melanocytes and FM55 melanoma cells express cyclooxygenase-1 and -2 (COX-1 and -2) and thus have the capability to produce prostaglandins. The FM55 cells produced predominantly PGE2 and PGF2alpha, whereas the HaCaT keratinocyte cell line produced mainly PGE2. The anti-inflammatory peptide, alpha-melanocyte stimulating hormone (alpha-MSH), reduced prostaglandin production in FM55 and HaCaT cells and reversed the effect of the pro-inflammatory cytokine TNF-alpha in the former. These results indicate that melanocytes produce prostaglandins and that alpha-MSH, by inhibiting this response, may play an important role in regulating inflammatory responses in the skin.
References
Nov 1, 1992·Pigment Cell Research·Y TomitaH Tagami
Oct 1, 1993·The Journal of Investigative Dermatology·M GreweJ Krutmann
May 15, 1998·The British Journal of Dermatology·S J HedleyS M Neil
Jul 11, 1998·Carcinogenesis·S Y BuckmanA P Pentland
Feb 26, 2000·The Journal of Investigative Dermatology·M TsatmaliA J Thody
May 8, 2000·International Journal of Cancer. Journal International Du Cancer·Y HigashiT Kanzaki
May 24, 2000·The Journal of Biological Chemistry·J W HaycockS MacNeil
Jul 14, 2000·Physiological Reviews·A SlominskiS Solomon
Oct 26, 2001·The Journal of Investigative Dermatology·L E RhodesP S Friedmann
Jan 19, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Marina TsatmaliAnthony J Thody
Apr 20, 2002·Expert Review of Molecular Diagnostics·Michael P Murphy
May 10, 2002·Journal of Cutaneous Medicine and Surgery·Kathleen J Smith, Henry Skelton
Jun 28, 2002·Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer·David Bishop-BaileyJane A Mitchell
Sep 3, 2002·Survey of Ophthalmology·Johan W StjernschantzPer J Wistrand
Oct 9, 2002·Oncogene·Michael A BachelorGim T Bowden
Dec 18, 2002·The Journal of Investigative Dermatology·Manar MoustafaJohn W Haycock
Jul 10, 2003·Annals of the New York Academy of Sciences·Thomas A LugerMarkus Böhm
Jul 10, 2003·Annals of the New York Academy of Sciences·Ana Luisa KadekaroZalfa A Abdel-Malek
Nov 13, 2003·British Journal of Cancer·P EvesS Mac Neil
Dec 23, 2003·Cancer Biology & Therapy·A-C GouletMark A Nelson
Dec 24, 2003·Investigative Ophthalmology & Visual Science·Kenji ShiratoriShigeaki Ohno
Citations
Oct 12, 2012·Amino Acids·Nadine TandlerJens Pietzsch
Mar 20, 2010·Pigment Cell & Melanoma Research·Karl GledhillDesmond J Tobin
Mar 9, 2010·Journal of Comparative Pathology·I PiresF L Queiroga
May 10, 2006·Clinical and Experimental Dermatology·G W M Millington
Aug 17, 2006·The Journal of Investigative Dermatology·Markus BöhmJosé Carlos García-Borrón
Mar 8, 2005·Experimental Cell Research·Glynis ScottAlice Pentland
Oct 18, 2014·Inflammation·Lisa Carole LoramSheila Sturgill-Koszycki
May 21, 2010·Experimental Dermatology·Mojgan MasoodiAnthony J Thody
Jul 10, 2008·Endocrine Reviews·Thomas BrzoskaMarkus Böhm
May 11, 2019·Journal of Cosmetic Dermatology·Andréia Feital Costa PereiraSamara Eberlin
Apr 18, 2012·Experimental Dermatology·Ji Y KimSang H Oh
Aug 2, 2019·Cancer Biology & Therapy·Lauren E DavisAlan J Tackett
Nov 5, 2005·Molecular Pharmacology·Guei-Sheung LiuMing-Hong Tai
Nov 29, 2014·Experimental Dermatology·Kênia Soares de SouzaCláudia Rocha Carvalho
Apr 5, 2019·Oncology Letters·Mihaela AntoheGabriela Turcu
Oct 28, 2019·Frontiers in Endocrinology·Wei WangYa-Xiong Tao
Aug 28, 2020·Frontiers in Pharmacology·Antonio RecchiutiMario Romano
Feb 26, 2020·Applied Biochemistry and Biotechnology·Muhammad Fuad Hilmi YusofAhmad Azlina
May 19, 2005·Cancer Research·Julien AckermannFriedrich Beermann
Aug 5, 2019·European Journal of Pharmacology·Seong-Hui Eo, Song Ja Kim
Aug 30, 2008·Biochimica Et Biophysica Acta·Mariagrazia Rita ScuderiMario Alberghina
Sep 14, 2021·Frontiers in Cell and Developmental Biology·Han ZhaoLan Gong