Prostaglandin production by melanocytic cells and the effect of alpha-melanocyte stimulating hormone

FEBS Letters
Anna NicolaouAnthony J Thody

Abstract

Prostaglandins are potent mediators of the inflammatory response and are also involved in cancer development. In this study, we show that human melanocytes and FM55 melanoma cells express cyclooxygenase-1 and -2 (COX-1 and -2) and thus have the capability to produce prostaglandins. The FM55 cells produced predominantly PGE2 and PGF2alpha, whereas the HaCaT keratinocyte cell line produced mainly PGE2. The anti-inflammatory peptide, alpha-melanocyte stimulating hormone (alpha-MSH), reduced prostaglandin production in FM55 and HaCaT cells and reversed the effect of the pro-inflammatory cytokine TNF-alpha in the former. These results indicate that melanocytes produce prostaglandins and that alpha-MSH, by inhibiting this response, may play an important role in regulating inflammatory responses in the skin.

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Citations

Oct 12, 2012·Amino Acids·Nadine TandlerJens Pietzsch
Mar 9, 2010·Journal of Comparative Pathology·I PiresF L Queiroga
May 10, 2006·Clinical and Experimental Dermatology·G W M Millington
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Oct 18, 2014·Inflammation·Lisa Carole LoramSheila Sturgill-Koszycki
May 11, 2019·Journal of Cosmetic Dermatology·Andréia Feital Costa PereiraSamara Eberlin
Apr 18, 2012·Experimental Dermatology·Ji Y KimSang H Oh
Aug 2, 2019·Cancer Biology & Therapy·Lauren E DavisAlan J Tackett
Nov 29, 2014·Experimental Dermatology·Kênia Soares de SouzaCláudia Rocha Carvalho
Apr 5, 2019·Oncology Letters·Mihaela AntoheGabriela Turcu
Oct 28, 2019·Frontiers in Endocrinology·Wei WangYa-Xiong Tao
Aug 28, 2020·Frontiers in Pharmacology·Antonio RecchiutiMario Romano
Sep 14, 2021·Frontiers in Cell and Developmental Biology·Han ZhaoLan Gong

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