Prostaglandin receptor signalling and function in human endometrial pathology

Trends in Endocrinology and Metabolism : TEM
Henry N Jabbour, Kurt J Sales

Abstract

Prostaglandins are bioactive lipids that exert an autocrine or paracrine function by binding to specific G-protein-coupled receptors (GPCRs) to activate intracellular signalling and gene transcription. Prostaglandins are key regulators of reproductive processes, including ovulation, implantation and menstruation. Prostaglandins have been ascertained to have a role in various pathological changes of the reproductive tract including menorrhagia, dysmenorrhea, endometriosis and cancer. Although the mechanism by which prostaglandins modulate these changes remains unclear, much evidence suggests that prostaglandins and their receptors and downstream signalling pathways are involved in angiogenesis and in alterations in cell adhesion, morphology, motility, invasion and metastases. The potential role of prostaglandin receptors in pathological changes of the endometrium has significance for the future development of therapeutic interventions.

References

Jan 1, 1978·Journal of Reproduction and Fertility·A A TempletonR W Kelly
Dec 1, 1993·Baillière's Clinical Obstetrics and Gynaecology·A F Haney
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·M TsujiiR N DuBois
Feb 12, 1998·Proceedings of the Society for Experimental Biology and Medicine·K SubbaramaiahA J Dannenberg
Apr 1, 1998·Journal of the National Cancer Institute·D HwangE Levine
Apr 29, 1998·Annual Review of Physiology·V L Schuster
Jun 5, 1998·Trends in Pharmacological Sciences·K R BleyJ A Smith
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·G A GrossL J Muglia
Apr 21, 1999·Current Opinion in Cell Biology·L M LuttrellR J Lefkowitz
Oct 3, 1999·Physiological Reviews·S NarumiyaF Ushikubi
Sep 6, 2000·Nature Medicine·C J TorranceC M Discafani
Mar 3, 2001·Neoplasia : an International Journal for Oncology Research·B J TongS K Dey
Mar 30, 2001·The Journal of Biological Chemistry·H ShengR N DuBois
Jul 19, 2002·International Journal of Cancer. Journal International Du Cancer·Isao NagatsukaKosei Hirakawa
Sep 12, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Blaithin McMahonCatherine Godson
Sep 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·N V ChandrasekharanDaniel L Simmons
Oct 9, 2002·The Journal of Biological Chemistry·Hiromichi FujinoJohn W Regan
Nov 16, 2002·Prostaglandins & Other Lipid Mediators·Ikuo Morita
Nov 16, 2002·Prostaglandins & Other Lipid Mediators·Victor L Schuster
Dec 10, 2002·Reproductive Biomedicine Online·Georg Kunz, Gerhard Leyendecker
Apr 8, 2003·The Journal of Clinical Endocrinology and Metabolism·Stuart A Milne, Henry N Jabbour
Jun 25, 2003·Biochemical and Biophysical Research Communications·Guido EiblOscar J Hines
Jun 26, 2003·The Journal of Biological Chemistry·F Gregory BuchananRaymond N DuBois
Aug 19, 2003·European Journal of Pharmacology·Valérie CapraG Enrico Rovati
Sep 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rama PaiAndrzej S Tarnawski
Sep 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Sakhila K BanuMichel A Fortier

❮ Previous
Next ❯

Citations

Jul 10, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Z ChengA P F Flint
Oct 2, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Henry N JabbourJane E Norman
Sep 3, 2014·Pathology Research International·Anthonio AdefuyeKurt Jason Sales
Jan 23, 2010·BMC Cell Biology·Margaret C KeightleyKurt J Sales
Apr 30, 2010·Biology of Reproduction·Rose Ellen DixonSean M Ward
May 5, 2011·Menopause : the Journal of the North American Menopause Society·Hua ZhangLena Sahlin
Mar 2, 2013·American Journal of Respiratory and Critical Care Medicine·Hong LiDarryl C Zeldin
Dec 5, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Patrizia CarrarelliFelice Petraglia
Nov 21, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·JeHoon LeeJoe A Arosh
Sep 1, 2015·Prostaglandins & Other Lipid Mediators·Na HuangJinshan Cao
Jul 21, 2015·Microvascular Research·Khuyen Gia HoangNenad Petrovic
Oct 21, 2015·Prostaglandins & Other Lipid Mediators·Ilona Kowalczyk-ZiebaIzabela Woclawek-Potocka
Apr 29, 2008·Prostaglandins & Other Lipid Mediators·John CuppolettiRyuji Ueno
Feb 6, 2007·Pharmacology, Biochemistry, and Behavior·Juan Manuel Ramírez-OrduñaCarlos Beyer
Nov 1, 2006·Fertility and Sterility·Pasquale FlorioFelice Petraglia
Apr 19, 2005·American Journal of Reproductive Immunology : AJRI·Abdorrahman S AlghamdiMats H T Troedsson
Apr 3, 2014·The Journal of Obstetrics and Gynaecology Research·Koji NakagawaRikikazu Sugiyama
Aug 4, 2011·Journal of Thrombosis and Haemostasis : JTH·F PeyvandiM Menegatti
Jul 8, 2011·American Journal of Reproductive Immunology : AJRI·Najwa A RashidKristina Gemzell-Danielsson
Jul 23, 2016·Journal of Immunology Research·Anthonio O AdefuyeArieh A Katz
Jan 24, 2009·Physiology & Behavior·Oscar González-FloresAnne M Etgen
Jun 25, 2005·Current Opinion in Obstetrics & Gynecology·Julia Osei, Hilary Critchley
Jul 17, 2007·American Journal of Reproductive Immunology : AJRI·Osmond J D'Cruz, Fatih M Uckun
Oct 11, 2011·Cell Biology International·Dewi Kenneth RowlandsHsiao Chang Chan
Jun 28, 2011·Menopause : the Journal of the North American Menopause Society·JoAnn V Pinkerton
Mar 26, 2014·Current Opinion in Rheumatology·Meredith ProvostMegan E B Clowse

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.