Prostaglandin release by cultured endometrial tissues after challenge with lipopolysaccharide and tumor necrosis factor α, in relation to the estrous cycle, treatment with medroxyprogesterone acetate, and pyometra

Theriogenology
Ewelina Jursza-PiotrowskaMarta Jolanta Siemieniuch

Abstract

To better understand the pathogenesis of endometrial changes in cats associated with administration of progestagen contraceptives and with pyometra, we examined local variability of the prostaglandin synthesis system after challenge with either tumor necrosis factor α (TNF-α) or lipopolysaccharide (LPS) in organ cultures of endometrial tissues derived from cyclic cats, cats treated with medroxyprogesterone acetate (MPA), or cats with pyometra, as well as in cultured endometrial epithelial and stromal cells. In addition, spontaneous prostaglandin secretion was compared in endometria from different experimental groups. Data gathered in the present study show that the concentration of PGE2 in supernatants was increased only in endometrial organ cultures from cats with pyometra (P < 0.001) compared with other groups. This was also true for PGF2α in pyometra, compared with cats treated either short- or long-term with MPA and cats during late diestrus (P < 0.001), anestrus (P < 0.01), and estrus and middiestrus (P < 0.05). Treatment with LPS and TNF-α combined stimulated PGE2 secretion in all groups compared with the control (P < 0.001 for endometria of cats during anestrus or middiestrus, cats treated short-term with MPA, and those ...Continue Reading

References

Nov 1, 1975·Biology of Reproduction·S R PaapeG H Stabenfeldt
Jul 1, 2004·Reproduction in Domestic Animals = Zuchthygiene·B HoffmannP Papa
Oct 26, 2005·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Sheng Zhao, Russell D Fernald
May 6, 2006·American Journal of Reproductive Immunology : AJRI·Gisela SobollCharles R Wira
Sep 15, 2009·Theriogenology·R HagmanH Kindahl
Mar 26, 2010·Animal Reproduction Science·Marta J SiemieniuchKiyoshi Okuda
Jan 1, 2010·Polish Journal of Veterinary Sciences·M J SiemieniuchK Okuda
Dec 1, 2002·The Veterinary Quarterly·C F Agudelo
Dec 3, 2014·Reproductive Biology·Ewelina JurszaMarta J Siemieniuch
Dec 8, 2014·Theriogenology·E JurszaM J Siemieniuch

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