Prostaglandin release by zygotes and endometria of pregnant rabbits

Biology of Reproduction
M J HarperK Rajkumar

Abstract

When 4-day rabbit zygotes were incubated for 1 h at 37 degrees C in vitro, very little prostaglandin (PG) was released into the medium, and the concentration of PGs in the zygotes after incubation was also low. The release of prostaglandin E (PGE) and prostaglandin F (PGF) into the medium, and their concentration in the zygotes after incubation, increased sharply on Days 6 and 7 of pregnancy, reaching, by Day 7, values close to 200 ng of each PG released in 1 h per mg of protein. By contrast, endometrial samples on Days 4 and 5 of pregnancy released more PGF and less PGE than the zygotes of the same ages on a per mg of protein basis, and on Days 6 and 7, less of both PGs. Furthermore, endometrial concentrations of PGs after incubation, except for PGF on Day 4, were always lower than values for zygotes. Endometrial concentrations of PGs on Day 6 were lower before than after incubation. Although there was a slight upward trend in PG release by endometrial samples with increasing length of pregnancy, the changes were minimal and, in the case of PGE, none of the mean values exceeded 1 ng per mg of protein. In 7-day blastocysts, high levels of both PGF and PGE were found in the blastocoelic fluid, and these did not change during the...Continue Reading

Citations

Dec 1, 1988·European Journal of Obstetrics, Gynecology, and Reproductive Biology·S HayashiT Mori
Feb 1, 1986·Prostaglandins·M KasamoT Shimizu
Jul 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·O IshiharaT Shimizu
Apr 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M A JonesM J Harper
Jun 1, 1992·Baillière's Clinical Obstetrics and Gynaecology·M J Harper
Jul 1, 1996·The Journal of International Medical Research·K KanayamaT Endo
Jul 15, 1991·Biochemical and Biophysical Research Communications·M MomoedaY Nagai

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