Prostaglandin release during femtosecond laser-assisted cataract surgery: main inducer

Journal of Refractive Surgery
Tim SchultzH Burkhard Dick

Abstract

To investigate a possible correlation between intraocular prostaglandin concentrations and partial steps of laser-assisted cataract surgery. Aqueous humor was collected from 67 patients after laser-assisted cataract surgery pretreatment (only capsulotomy, only fragmentation, or both) and at the beginning of routine cataract surgery. Total prostaglandin levels were measured in all four groups using an enzyme-linked immunoassay. Significantly higher levels of aqueous humor prostaglandins were detected right after the full treatment (capsulotomy and fragmentation [330.6 ± 110.6 pg/mL; P = .01] or only laser capsulotomy [362.4 ± 117.5 pg/mL; P = .01]), whereas the control group showed lower values (52.5 ± 8.1 pg/mL). By itself, laser-assisted cataract surgery fragmentation did not lead to a prostaglandin increase (186.8 ± 114.0 pg/mL; P = .14). This study identified the anterior capsulotomy as the main trigger for an increase of prostaglandins in the aqueous humor immediately after laser-assisted cataract surgery. Optimized energy settings in combination with nonsteroidal anti-inflammatory drugs might help reduce the phenomenon of laser-induced miosis.

References

Feb 1, 1983·The British Journal of Ophthalmology·H C Keulen-de VosJ T Jansen
Dec 17, 2009·Journal of Refractive Surgery·Zoltan NagyMelvin Sarayba
Jun 28, 2011·Journal of Cataract and Refractive Surgery·Neil J FriedmanWilliam W Culbertson
Mar 1, 2012·Ophthalmology·Shveta Jindal BaliGerard Sutton
Dec 13, 2012·Journal of Refractive Surgery·Ina Conrad-HengererH Burkhard Dick
Jul 31, 2013·Journal of Cataract and Refractive Surgery·H Burkhard Dick, Tim Schultz
Oct 8, 2013·Journal of Refractive Surgery·H Burkhard DickTim Schultz
Nov 10, 2013·Journal of Refractive Surgery·Tim SchultzH Burkhard Dick
Apr 26, 2014·Journal of Refractive Surgery·H Burkhard Dick, Tim Schultz
Apr 29, 2014·Journal of Cataract and Refractive Surgery·Ronald Yeoh

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Citations

Dec 26, 2015·Journal of Cataract and Refractive Surgery·Shaun Y P EweBrendan J Vote
Dec 15, 2015·Journal of Refractive Surgery·Tim SchultzH Burkhard Dick
Sep 28, 2015·Survey of Ophthalmology·Dilraj S GrewalH Burkhard Dick
Jul 21, 2015·Journal of Cataract and Refractive Surgery·Carmen OakleyBrendan J Vote
Nov 26, 2015·Eye and Vision·Antonis AristeidouEleftherios I Paschalis
Jul 5, 2016·Journal of Cataract and Refractive Surgery·H Burkhard Dick, Tim Schultz
Dec 7, 2017·Indian Journal of Ophthalmology·Nicole Shu-Wen ChanSoon-Phaik Chee
Jan 21, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Hui ChenWeirong Chen
Oct 16, 2018·European Journal of Ophthalmology·Gian Maria CavalliniTommaso Verdina
Aug 7, 2017·Asia-Pacific Journal of Ophthalmology·Joobin Hooshmand, Brendan J Vote
Nov 20, 2019·Current Opinion in Ophthalmology·Andrzej Grzybowski, Piotr Kanclerz
Nov 2, 2016·Current Opinion in Ophthalmology·Ashvin Agarwal, Soosan Jacob
Jun 9, 2020·European Journal of Ophthalmology·Piotr Kanclerz, Jorge L Alio
Nov 7, 2019·Vestnik oftalmologii·Yu N YusefE G Ryzhkova
Oct 6, 2017·Vestnik oftalmologii·K S AvetisovE D Sakalova
May 1, 2020·Journal of Ophthalmology·Sang Beom HanJodhbir S Mehta
Apr 23, 2019·American Journal of Ophthalmology·Harrish NithianandanSohel Somani
Jul 15, 2015·Journal of Refractive Surgery·Marco RossiMuna Al Oum
May 18, 2021·PloS One·Alireza MirshahiKatharina A Ponto
Jul 23, 2020·Archivos de la Sociedad Española de Oftalmología·A PiñeroJ L Alió
Oct 10, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jae Hyuck LeeHungwon Tchah

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