PMID: 7225303Apr 1, 1981Paper

Prostaglandin synthesis in the endometrium of women with ovular dysfunctional uterine bleeding

British Journal of Obstetrics and Gynaecology
S K SmithD T Baird

Abstract

The endogenous concentrations of prostaglandins F2 alpha (PGF 2 alpha) and E (PGE) were measured during the luteal phase of the menstrual cycle in the endometrium from 14 women with unexplained menorrhagia (measured menstrual blood loss in excess of 50 ml) and 15 women with normal menses (blood loss 50 ml or less). Although there was no significant difference in the PGF 2 alpha/PGE ratio between the two groups, this ratio was significantly lower in the endometrium from eight of the women whose blood loss exceeded 90 ml (p less than 0.05). There was a significant inverse correlation between the PGF 2 alpha/PGE ratio and blood loss (r = 0.36, p less than 0.025). The synthetic capacity of the endometrium was assessed by incubation of the tissue with 14C arachidonic acid. Endometria from nine women with unexplained menorrhagia synthesized more PGE2 than PGF 2 alpha, whereas the converse was true with 11 control endometria. Consequently the PGF2 alpha/PGE2 ratio was significantly reduced in the former group (p less than 0.025). Oestradiol-17 beta (200 microM) and to a greater extent 2 hydroxy oestradiol (200 microM) increased the total prostaglandin synthesis by the endometria, but did not significantly alter the PGF2 alpha/PGE2 rat...Continue Reading

References

Nov 1, 1979·Journal of Reproduction and Fertility·J WatsonK S Dodson
Jul 1, 1977·Clinical Endocrinology·P F van LookD T Baird
Jan 1, 1978·British Journal of Obstetrics and Gynaecology·J GuillebaudA C Turnbull
Jan 1, 1977·Prostaglandins·F F SunJ C McGuire
Nov 1, 1979·Prostaglandins·M H Abel, R W Kelly
Nov 1, 1977·Clinical Endocrinology·P F Van LookD T Baird
Jan 1, 1977·Journal of Reproduction and Fertility·R J ScaramuzziA G Wheeler
Apr 1, 1975·American Journal of Obstetrics and Gynecology·E J SinghF P Zuspan
Mar 1, 1975·Fertility and Sterility·M J LevittJ B Josimovich
Feb 1, 1975·British Journal of Obstetrics and Gynaecology·M J KeirseA C Turnbull
Jan 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·M Shemesh, W Hansel
May 1, 1976·British Journal of Obstetrics and Gynaecology·E A WillmanS G Clayton
Sep 1, 1973·The Journal of Clinical Endocrinology and Metabolism·I S FraserD T Baird
Jun 1, 1970·British Journal of Haematology·H LacknerJ Pearson
Jan 1, 1966·Acta Obstetricia Et Gynecologica Scandinavica·L HallbergG Rybo
Apr 1, 1959·The Journal of Obstetrics and Gynaecology of the British Empire·J B BROWNG D MATTHEW
Apr 1, 1964·The Journal of Obstetrics and Gynaecology of the British Commonwealth·F E HYTTENA I KLOPPER
Apr 1, 1965·The Journal of Obstetrics and Gynaecology of the British Commonwealth·V R PICKLESG N SMITH
Aug 28, 1965·Lancet·A JACOBS, E B BUTLER
Jan 1, 1974·The Journal of Physiology·J DownieM Wunderlich

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Citations

Aug 2, 2012·Reviews in Endocrine & Metabolic Disorders·Malcolm G Munro
Jan 1, 1987·Journal of Steroid Biochemistry·R C BonneyS Franks
Sep 1, 1986·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A CanoL Abad
Feb 1, 1982·Prostaglandins·M C ReesA C Turnbull
May 1, 1984·Prostaglandins, Leukotrienes, and Medicine·L M DemersA C Turnbull
Mar 1, 1985·Prostaglandins, Leukotrienes, and Medicine·I T CameronD T Baird
Oct 1, 1987·Prostaglandins, Leukotrienes, and Medicine·I T CameronD T Baird
Sep 1, 1987·Prostaglandins, Leukotrienes, and Medicine·M Yamaguchi, N Mori
Jan 13, 2000·Fertility and Sterility·F VesceG Gotti
Dec 1, 1996·European Journal of Obstetrics, Gynecology, and Reproductive Biology·D T BairdR W Kelly
Jul 15, 2009·Journal de gynécologie, obstétrique et biologie de la reproduction·C Huchon, X Fritel
Oct 2, 2003·Prostaglandins & Other Lipid Mediators·K J Sales, H N Jabbour
Jan 22, 2005·Seminars in Hematology·Francesco Rodeghiero, Giancarlo Castaman
Sep 8, 2001·Current Opinion in Obstetrics & Gynecology·M G Munro
Apr 5, 2005·Clinical Obstetrics and Gynecology·Rameet H Singh, Paul Blumenthal
Nov 4, 2006·Clinical Obstetrics and Gynecology·Malcolm G Munro
May 22, 2007·Clinical Obstetrics and Gynecology·Malcolm G Munro
Dec 1, 1990·British Journal of Obstetrics and Gynaecology·L Birgerson, R Bright-Paul
Mar 1, 1995·British Journal of Pharmacology·T J Gelety, G Chaudhuri
Mar 1, 1997·Acta Obstetricia Et Gynecologica Scandinavica·B G MolnárA L Magos
Sep 10, 1983·British Medical Journal·M G Elder
Nov 24, 1999·BMJ : British Medical Journal·A Prentice
Jun 17, 2011·The Journal of Clinical Endocrinology and Metabolism·Jacqueline A MaybinHilary O D Critchley
Nov 13, 2003·Reproduction : the Official Journal of the Society for the Study of Fertility·Kurt J Sales, Henry N Jabbour
Apr 2, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·S BattersbyH N Jabbour
Sep 8, 2012·International Journal of Women's Health·Henri Leminen, Ritva Hurskainen
Aug 22, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Richard G Lea, Olivier Sandra
Jul 6, 2013·Women's Health·Marina Berbic, Ian S Fraser
Dec 6, 2007·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Rene Druckmann
Apr 11, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Hugo MaiaElsimar M Coutinho
Sep 6, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Efthimios DeligeoroglouGeorge Creatsas
Jul 5, 2010·Pharmaceuticals·Anna Livshits, Daniel S Seidman
Oct 27, 2007·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Hugo Júnior Maia, Julio Casoy
Oct 30, 2004·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·M Hickey, N H Morris
Jun 1, 1985·American Journal of Obstetrics and Gynecology·O Ylikorkala, U M Mäkilä

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