Prostaglandin synthesis inhibitors in ulcerative colitis: flurbiprofen compared with conventional treatment

Prostaglandins
D S Rampton, G E Sladen

Abstract

It has been suggested that prostaglandins (PGs) play a pathogenetic role in ulcerative colitis (UC) and that treatment with inhibitors of PG synthesis might be of therapeutic benefit. We therefore performed a one-week open trial to compare the effects of oral flurbiprofen with those of conventional therapy with corticosteroids and sulphasalazine, in two groups of patients with active UC. Mean rectal mucosal release of PGE2, measured by in vivo rectal dialysis, fell by 44% (P less than 0.05) after one week's conventional treatment, and the effect of flurbiprofen was not significantly different. However, the patients given flurbiprofen fared significantly worse than those given conventional therapy in respect of rectal mucosal appearance at sigmoidoscopy (P = 0.01), rectal electrical potential difference (p less than 0.01), rectal mucosal sodium absorption (P = 0.01) and rectal bleeding (P less than 0.05). Furthermore, flurbiprofen-treated patients showed significant deteriorations in rectal potential difference (P less than 0.05) and sodium absorption (P less than 0.05). These results do not support the hypothesis that increased mucosal PG production is of major pathogenetic importance in active UC, and suggest that flurbiprofen...Continue Reading

References

Mar 8, 1975·Lancet·N Levy, E Gaspar
Jan 1, 1979·Gut·T A Miller, E D Jacobson
Dec 1, 1977·British Journal of Pharmacology·A BennettH L Stockley
Jul 29, 1975·European Journal of Clinical Investigation·F DrayJ Maclouf
Jan 11, 1964·British Medical Journal·J H BARONJ E LENNARD-JONES

❮ Previous
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Citations

Jan 19, 2007·Inflammatory Bowel Diseases·James JuppAnthony P Sampson
Feb 1, 1987·Digestive Diseases and Sciences·R N Fedorak, M Field
Jun 1, 1992·Digestive Diseases and Sciences·T S Gaginella, R E Walsh
Dec 1, 1987·Digestive Diseases and Sciences·B M PeskarH Goebell
Dec 1, 1985·Digestive Diseases and Sciences·C J HawkeyB J Whittle
Mar 1, 1988·Digestive Diseases and Sciences·R SchumertR D Zipser
Dec 1, 1995·Diseases of the Colon and Rectum·N M Davies
Nov 1, 1981·Diseases of the Colon and Rectum·N I McNeil, D S Rampton
Jul 1, 1995·Gastroenterology·C E Eberhart, R N Dubois
Jun 1, 1985·Prostaglandins·A RobertM J Ruwart
Dec 1, 1994·Prostaglandins·M D StrattonW E Longo
Aug 1, 1994·Pharmacology & Therapeutics·S P Travis, D P Jewell
Apr 1, 1983·Prostaglandins, Leukotrienes, and Medicine·C J Hawkey, D S Rampton
Jun 27, 2000·Prostaglandins & Other Lipid Mediators·B Mohajer, T Y Ma
Dec 12, 1981·Lancet·C J Hawkey
Dec 12, 1981·Lancet·C A Stiller, L M Kinnier Wilson
Jan 21, 1984·Lancet·D S Rampton
Jan 21, 1984·Lancet·T ThulinJ Castenfors
Jul 1, 1997·Inflammatory Bowel Diseases·S Urayama, E B Chang
Dec 1, 1984·Gut·D S Rampton, C J Hawkey
Jan 1, 1986·Postgraduate Medical Journal·K W Somerville, C J Hawkey
Aug 1, 1986·Postgraduate Medical Journal·S RaviE C Keat
Jan 1, 1992·Mediators of Inflammation·N A PunchardR P Thompson
Oct 15, 2014·Scandinavian Journal of Gastroenterology·Charlotte L KvasnovskyIngvar Bjarnason
Jul 26, 2005·Joint, Bone, Spine : Revue Du Rhumatisme·Gérard Thiéfin, Laurent Beaugerie
Apr 1, 1982·The New England Journal of Medicine·J B Kirsner, R G Shorter
Jan 1, 1990·Scandinavian Journal of Gastroenterology. Supplement·S B Hanauer
Jan 1, 1989·Scandinavian Journal of Gastroenterology. Supplement·L Aabakken, M Osnes
Apr 1, 1987·Journal of Clinical Pharmacology·M A Peppercorn
Aug 11, 1992·The American Journal of Medicine·D L Geier, P B Miner
Jan 1, 1987·Scandinavian Journal of Gastroenterology·D S Rampton
Mar 31, 2001·The American Journal of Gastroenterology·T R Koch
May 1, 1981·Postgraduate Medical Journal·D S Rampton, G E Sladen
Feb 1, 1991·DICP : the Annals of Pharmacotherapy·J M Fitzgerald, T D Marsh

❮ Previous
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