Prostaglandins and ischemic heart disease

The American Journal of Medicine
P D HirshL D Hillis

Abstract

There is an abundance of information suggesting that prostaglandins are involved in the development and clinical expression of atherosclerosis. Many studies demonstrate a relationship between prostaglandins and the risk factors for peripheral and coronary artery disease. Thus, part of the mechanism by which hyperlipidemia, diabetes mellitus, smoking, hypertension, sex hormones, age, heredity, emotional stress and diet contribute to the development and progression of atherosclerosis may be through an imbalance between thromboxane A2 and prostaglandin I2. Recent studies show a temporal relationship between acute ischemic events (specifically, unstable angina) and a transcardiac increase in thromboxane B2, while others demonstrate a salutary effect of disaggregatory and vasodilatory prostaglandins in such patients. If prostaglandins and thromboxane prove important in ischemic vascular disease, attention will be directed at the correction of their pathologic imbalance. This may be accomplished by dietary manipulation as well as by the development of prostaglandin receptor antagonists or inhibitors of specific prostaglandin pathways.

Citations

Dec 1, 1991·Journal of Cardiothoracic and Vascular Anesthesia·R Sanchez, M Wee
Mar 1, 1991·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M Y AbeywardenaJ S Charnock
Nov 1, 1984·International Journal of Cardiology·C Kawai
Oct 1, 1988·The American Journal of Cardiology·R L FeldmanK M Verbust
Aug 1, 1985·Journal of the American College of Cardiology·H ShimokawaM Nakamura
Jan 25, 1985·The American Journal of Cardiology·M D WinnifordL D Hillis
Dec 1, 1984·The American Journal of Cardiology·J T WillersonL M Buja
Oct 1, 1989·Journal of Internal Medicine·A SjögrenB Fallgren
Dec 1, 1986·Journal of Cardiac Surgery·W J GreeleyW D Watkins
Aug 29, 2000·Anesthesia and Analgesia·H KernM Schlame
Feb 1, 1993·Circulation·J D AltmanR J Bache
May 1, 1985·Basic Research in Cardiology·S R JollyB R Lucchesi
Jan 1, 1985·Acta Medica Scandinavica. Supplementum·H Vapaatalo
Jan 1, 1985·Medicinal Research Reviews·R C NickolsonH Vorbrüggen
Jan 1, 1988·Upsala Journal of Medical Sciences·S Holm, A Nachemson
Jan 1, 1987·Pharmacotherapy·R E Nitz, V B Fiedler
Jan 1, 1987·European Journal of Clinical Pharmacology·A M GrauholtJ Wadt
Jan 1, 1984·European Journal of Clinical Pharmacology·P GrandeT Corell
Jun 3, 2021·International Journal of Molecular Sciences·Alejandro Ogazon Del ToroArturo Ponce
Aug 1, 1987·Journal of Cardiothoracic Anesthesia·W J GreeleyJ G Reves
Feb 1, 1989·Journal of the American College of Cardiology·D R Hathaway, K L March

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

© 2021 Meta ULC. All rights reserved