Prostaglandins and renin release: III. Effects of PGE1, E2 F2 alpha and D2 on renin release from rabbit renal cortical slices

Prostaglandins
A R WhortonJ A Oates

Abstract

We have investigated the direct effects of prostaglandins E1, E2, F2 alpha and D2 on renin release from rabbit renal cortical slices. Prostaglandin E1 (PGE1) was the most potent stimulant of renin release, while PGE2 was 20-30 fold less active. PGF2 alpha was found not to be an inhibitor of renin release as reported by others, but rather a weak agonist. PGD2 up to a concentration of 10 microgram/ml had no activity in this system. That the stimulation of renin release by PGE1 is a direct effect is supported by the finding that PGE1-induced release is not blocked by L-propranolol or by delta 5,8,11,14-eicosatetraynoic acid (ETYA), a prostaglandin synthesis inhibitor. The fatty acid precursor of PGE1, delta 8,11,14-eicosatrienoic acid, also stimulated renin release, an effect which was blocked by ETYA. In addition to the above findings, ethanol, a compound frequently used to dissolve prostaglandins, was shown to inhibit renin release.

References

Sep 1, 1977·Prostaglandins·T V Zenser, B B Davis
Nov 1, 1978·Proceedings of the Society for Experimental Biology and Medicine·J L OsbornM D Bailie
May 1, 1977·Circulation Research·J YunH Smith
Jun 16, 1977·Nature·P M BolgerL M Slotkoff
Sep 1, 1967·Canadian Journal of Physiology and Pharmacology·R BoucherJ Genest
Mar 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·A M MichelakisG W Liddle
Oct 1, 1974·European Journal of Pharmacology·C LarssonE Anggård

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Citations

Aug 1, 1985·Prostaglandins, Leukotrienes, and Medicine·G A LopezS Rivas
Jul 1, 1986·Prostaglandins, Leukotrienes, and Medicine·G A LopezJ Tantisira
Jan 1, 1989·Comparative Biochemistry and Physiology. A, Comparative Physiology·G A LopezM Natividad
Jun 1, 1983·Drug and Alcohol Dependence·J Parantainen
Jun 1, 1984·British Journal of Pharmacology·A E BardenR Vandongen
Jun 22, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ulla G FriisOle Skøtt
Jul 17, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Eugene E LinR Ariel Gomez
Apr 29, 2004·American Journal of Physiology. Renal Physiology·Frank SchwedaArmin Kurtz

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