PMID: 6396653Nov 1, 1984Paper

Prostaglandins and the contractile effect of angiotensin I and II in the uterus isolated from ovariectomized rats. Influences of indomethacin and 17-beta estradiol

Prostaglandins, Leukotrienes, and Medicine
M A ChaudA L Gimeno

Abstract

The purpose of the present study was to explore whether, the stimulating contractile action of angiotensin II (AII) or of angiotensin I (AI), in uterine strips isolated from rats, either spayed or spayed and injected with 17-beta estradiol, was somehow linked to tissue generated prostaglandins (PGs). Indomethacin (10(-6)M), shifted to the left the dose-response curve for AII in preparations from ovariectomized animals; augmenting both, the efficacy and the potency of the agonist. Dose-response curves for AII were also explored in the presence of subthreshold concentrations of several exogenous PGs. PGE2 (10(-9) M) completely abolished the influence of indomethacin on the curve for AII; PGD2 (10(-9) M) did not evoke effects and PGF2 alpha (10(-9) M) only altered the threshold dose, the rest of the curve remaining similar to that obtained with indomethacin alone. The cumulative dose-response curve for AI, in strips isolated from ovariectomized rats, was comparable to that for AII and, the presence of indomethacin, only reduced the concentration for the threshold action of AI, in comparison to controls. Captopril (100 ng/ml), shifted to the right the dose-response curve for AI and indomethacin failed to alter the effects of AI in ...Continue Reading

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Citations

Apr 1, 1990·American Journal of Obstetrics and Gynecology·R A WordM L Casey

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