Prostaglandins and the dog stomach: effects of misoprostol on the proportion of mucosa to muscle and on the proportion of different epithelial cell types

Digestion
R A GoodladN A Wright

Abstract

Dogs were given an oral dose of 300 micrograms/kg/day of the prostaglandin E1 analogue, misoprostol for 11 weeks. The relative areas of the main components of the fundus and antrum per unit area of serosa were quantified. While the volume occupied by the muscle layers did not change, there was an increase in mucosal volume in both sites. The relative volume fraction of the main mucosal cell types was then determined by a point counting technique. Misoprostol very highly significantly increased the fraction of mucosal volume occupied by surface mucus cells, and also significantly decreased the volume fraction of the parietal cells.

Citations

Jan 1, 1995·Journal of Veterinary Internal Medicine·S A JohnstonM Marini
Dec 8, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Julian Lieb
May 31, 2003·Journal of Veterinary Internal Medicine·Deborah M WardMichele Marini
Jun 12, 2001·Medical Hypotheses·J Lieb
May 6, 2017·Wiley Interdisciplinary Reviews. Developmental Biology·Robert A Goodlad
May 8, 2002·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J Lieb

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