Prostaglandins as mediators of hypercalcemia associated with certain types of cancer.

The New England Journal of Medicine
H W SeyberthJ A Oates

Abstract

We investigated the role of prostaglandins in the hypercalcemia associated with neoplasia. In patients with hypercalcemia and solid tumors the excretion of the major urinary metabolite of the E prostaglandins, 7 alpha-hydroxy-5, 11-diketotetranorprostane-1, 16-dioic acid (PGE-M), was significantly greater than normal, P LESS THAN 0.01 (median of 58.4 and 7.1 ng per milligram of creatinine respectively). Slightly elevated values were seen in normocalcemic patients with solid tumors (14.3 ng per milligram). The levels of the metabolite were normal in hypercalcemic patients with either hematologic neoplasia or primary hyperparathyroidism. Immunoreactive parathyroid hormone was undetectable in the plasma of all hypercalcemic patients with solid tumors. Inhibition of prostaglandin synthesis by aspirin or indomethacin reduced excretion of both the urinary metabolite and serum calcium in six hypercalcemic patients with solid tumors and elevated excretion of the metabolite. These findings support the concept that prostaglandins are mediators of the hypercalcemia caused by certain solid tumors.

References

Feb 1, 1975·Life Sciences·M HambergB Samuelsson
Aug 11, 1975·Metabolism: Clinical and Experimental·E F VoelkelL Levine
Jul 1, 1975·The Journal of Clinical Endocrinology and Metabolism·R P RobertsonH W Adkison
Jun 1, 1970·Endocrinology·D C Klein, L G Raisz
Nov 14, 1974·The New England Journal of Medicine·G R MundyS E Salmon
Feb 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Nov 1, 1972·Biochemical and Biophysical Research Communications·M Hamberg
Jul 26, 1973·The New England Journal of Medicine·D PowellJ T Potts
Feb 1, 1973·Prostaglandins·O M BelielJ W Coburn
Apr 18, 1974·The New England Journal of Medicine·G R MundyD N Buell
Jul 1, 1974·The Journal of Clinical Investigation·R C BensonC D Arnaud
Jun 11, 1974·The New England Journal of Medicine·H D BreretonV T DeVita
Apr 9, 1974·Biochemistry·H T KeutmannJ L O'Riordan
Nov 1, 1967·Clinica Chimica Acta; International Journal of Clinical Chemistry·G G RudolphW J Ford
May 1, 1971·The American Journal of Medicine·B S RoofG S Gordan
Jan 1, 1967·The Journal of Clinical Endocrinology and Metabolism·L M SherwoodJ T Potts
Dec 1, 1972·The Journal of Clinical Investigation·G V SegreJ T Potts

❮ Previous
Next ❯

Citations

Feb 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·N S KriegerD A Bushinsky
Jun 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S J ScheinmanA F Stewart
Jun 1, 1989·Cancer Metastasis Reviews·P J Kelly, J A Eisman
Jan 1, 1982·Journal of Cancer Research and Clinical Oncology·M AltmannsbergerA Schauer
May 1, 1988·European Journal of Pediatrics·H W Seyberth, P G Kühl
Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·H A KulenkampffG Delling
Apr 1, 1994·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·E V MendoncaF C Rosa
May 1, 1984·Digestive Diseases and Sciences·P AttaliJ P Etienne
Jul 1, 1977·World Journal of Surgery·G Francini, M Galli
Feb 28, 1978·Calcified Tissue Research·A CaniggiaS Bombardieri
Jan 1, 1980·Calcified Tissue International·J H Dominguez, G R Mundy
Jan 1, 1980·Calcified Tissue International·H HeathG R Mundy
Jan 1, 1990·Calcified Tissue International·G R Mundy
Apr 1, 1991·Calcified Tissue International·M C Jungkeit, R A Chole
Dec 1, 1976·Irish Journal of Medical Science·J McPartlin, D Powell
Oct 6, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Giovanni MantovaniFilomena Panzone
Aug 1, 1977·Prostaglandins·H W SeyberthJ A Oates
Mar 1, 1992·Australian Family Physician·M E O'Neill, D M Coles
Mar 1, 1984·Prostaglandins, Leukotrienes, and Medicine·M StarczewskiB M Peskar
Apr 1, 1992·The Journal of Pediatrics·A LeonhardtH W Seyberth
Mar 1, 1990·Baillière's Clinical Endocrinology and Metabolism·G E GutierrezG R Mundy
Aug 25, 1977·The New England Journal of Medicine·J C LeeL J Deftos
Sep 21, 1978·The New England Journal of Medicine·J F Habener, J T Potts
Sep 6, 1979·The New England Journal of Medicine·H L BleichR W Gray
Feb 7, 1980·The New England Journal of Medicine·E S SirisR E Canfield

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.