Prostaglandins, glutamate and nitric oxide synthase mediate nitroglycerin-induced hyperalgesia in the formalin test

European Journal of Pharmacology
C TassorelliG Nappi

Abstract

Increasing evidence supports a possible role for nitric oxide (NO) in the transmission of pain signals and in the development of central mechanisms of hyperalgesia. Previously, we have shown that nitroglycerin, an NO donor, is able to induce a long-lasting hyperalgesic state in rats. Nitroglycerin-induced hyperalgesia can be detected as an increase in the nociceptive behavior evoked by the formalin test. In the present study we investigated the possible mediators in the nitroglycerin-induced hyperalgesic state. Male Sprague-Dawley rats were injected with nitroglycerin and pretreated with indomethacin, 5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclo-hepten-5,10-imine hydrogen maleate (MK-801) or N(omega)-nitro-L-arginine methyl ester (L-NAME). The results obtained showed that inhibition of prostaglandins or NO synthesis prevents nitroglycerin-induced hyperalgesia in Phase II of the formalin test. A similar inhibitory effect was also observed following pretreatment with the glutamate antagonist MK801. The present findings point to the role of prostaglandins, NO synthesis and glutamate activity in the induction of nitroglycerin-induced hyperalgesia.

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Citations

Jun 6, 2009·Cephalalgia : an International Journal of Headache·E A BatesA H Ahn
Jun 12, 2009·Cephalalgia : an International Journal of Headache·R GrecoC Tassorelli
Aug 31, 2013·BMC Neuroscience·Fabio DamascenoOlga M M S de Almeida
Mar 12, 2008·Calcified Tissue International·Rubens Ferreira de AlbuquerqueJoão Paulo Mardegan Issa
Apr 1, 2010·Experimental Neurology·Rosaria GrecoCristina Tassorelli
Oct 13, 2015·Journal of Pharmacological and Toxicological Methods·Sándor FarkasZsuzsanna Helyes
Feb 19, 2011·The Journal of Headache and Pain·Rosaria GrecoCristina Tassorelli
Oct 11, 2008·Toxicon : Official Journal of the International Society on Toxinology·Andréa C PessiniGlória E P Souza
Aug 10, 2010·Cephalalgia : an International Journal of Headache·Rosaria GrecoCristina Tassorelli
Aug 18, 2017·Cephalalgia : an International Journal of Headache·Rosaria GrecoCristina Tassorelli
Aug 13, 2008·Neuroreport·Dongyuan Yao, Barry J Sessle
May 24, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michael M NdengeleDaniela Salvemini
Feb 6, 2020·Pharmacological Reports : PR·Daniela H OliveiraLucielli Savegnago
Dec 6, 2017·BioMed Research International·Adriana E BulboacăAngelo C Bulboacă
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Thais Biondino Sardella GiornoPatricia Dias Fernandes
May 30, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Berenice Ovalle-MagallanesRachel Mata

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