Prostaglandins have limited actions on abnormalities of beating induced in cultured heart cells

Prostaglandins
G A CollinsM J Walker

Abstract

Prostaglandins are antiarrhythmic in a variety of situations including ischaemic arrhythmias, but the mechanisms involved are not known. In view of this, the protective actions of prostaglandins A2, E2, F1 alpha, F2 beta, and I2 against abnormalities of beating induced in cultured heart cells were investigated. Abnormalities of beating were induced in single cells by variety of agents including ouabain Ca++, K+, dinitrophenol (DNP), and toxic material from the jellyfish Cyanea. Abnormalities were assessed in terms of rate, rate range, subjective arrhythmic behaviour and percent cells beating. The prostaglandins (at 10(-7)-10(-5) M) were added with the arrhythmogenic agent to test for their ability to modify agent-induced beating abnormalities and were compared with lidocaine and quinidine. Prostaglandins alone had minimal direct effects on the cells and only minimally reduced responses to arrhythmogenic agents. The most protective prostaglandins, PGE2 and PGF1 alpha, tended to normalise beating behaviour most noticeably in DNP-treated cells, unlike lidocaine and quinidine which were effective against Ca++-induced changes while worsening those of K+. Thus, a general ability to protect disturbed cardiac cells is not seen with hi...Continue Reading

References

Jan 1, 1987·Toxicon : Official Journal of the International Society on Toxinology·J W Burnett, G J Calton
Dec 1, 1981·Journal of Pharmacological Methods·G A CollinsM J Walker

Citations

Jan 1, 1977·Toxicon : Official Journal of the International Society on Toxinology·M J Walker
Jan 1, 1977·Toxicon : Official Journal of the International Society on Toxinology·M J WalkerD V Godin
Jan 1, 1977·Annual Review of Pharmacology and Toxicology·P Hedqvist
Mar 1, 1978·The Journal of Clinical Investigation·P NeedlemanK C Nicolaou
Nov 1, 1977·Postgraduate Medical Journal·P J Piper
Feb 1, 1978·Circulation Research·M L Ogletree, A M Lefer
Mar 1, 1976·Journal of Molecular and Cellular Cardiology·K Goshima
Feb 1, 1963·Experimental Cell Research·I HARARY, B FARLEY

Related Concepts

Dinitrophenols
Quinidex
Jellyfish
Calcium
Potassium
Anti-Arrhythmia Agents
Ouabain
Myocardium
Antiarrhythmic [EPC]
Cyanea cnidaria

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