Prostaglandins may play a signal-coupling role during phagocytosis in Amoeba proteus

Cell and Tissue Research
R D PruschP Haberman

Abstract

Phagocytosis in Amoeba proteus can be induced with prostaglandins (PG). In addition, arachidonic acid (the fatty acid precursor to the PG-2 series) also induces phagocytosis. The induction of phagocytosis with arachidonic acid can be partially inhibited by the cyclooxygenase inhibitor indomethacin. Phagocytosis in the amoeba can also be induced with the chemotactic peptide N-formylmethionyl-leucylphenylalanine (NFMLP). The peptide presumably induces phagocytosis by interacting with receptors on the amoeba surface, which may initiate the release of arachidonic acid from membrane lipids. NFMLP-induced phagocytosis can also be partially inhibited by indomethacin. It is suggested that PG's or biochemically related substances may play a signal-coupling role during phagocytosis in the amoeba.

Citations

Jun 14, 2002·International Journal for Parasitology·Siddhartha DasKrishna Reddy
Dec 5, 2002·International Journal for Parasitology·Zakayi KabututuBruno Kilunga Kubata
Mar 14, 2003·International Journal for Parasitology·Zakayi KabututuBruno Kilunga Kubata
Nov 9, 2000·The Journal of Experimental Medicine·B K KubataO Hayaishi
Nov 6, 2002·The Journal of Experimental Medicine·Bruno Kilunga KubataYoshihiro Urade
May 29, 2007·Trends in Parasitology·Bruno Kilunga KubataYoshihiro Urade
Jun 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M Lamacka, J Sajbidor
Feb 4, 2006·Cell Death and Differentiation·K FigarellaM Duszenko

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