Prostaglandins of the A series inhibit Sendai virus replication in cultured cells

The Journal of General Virology
M G SantoroA Benedetto

Abstract

Prostaglandins of the A series (PGA) were shown to be potent inhibitors of Sendai virus replication in African green monkey kidney cells in culture. This antiviral activity was specific for PGA. The effective dose (4 micrograms/ml) was not toxic to the cells and did not alter either host cell metabolism of infectivity of the virus. PGA did not affect the first stages of virus replication and seemed to act by inhibiting virus maturation and/or budding from the cells. The antiviral action of PGA was pharmacological, was not mediated by cAMP and was completely reversible. Possible mechanisms of action include post-translational binding to virus proteins or interaction with interferon.

Citations

May 1, 1993·International Journal of Immunopharmacology·S PyoE P Mayer
Jun 3, 1999·Biochemical Pharmacology·M L van IerselP J van Bladeren
Jan 1, 1984·The Journal of Clinical Investigation·A EldorA Panet
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Jan 16, 1989·Biochemical and Biophysical Research Communications·N YamamotoY Nishiyama
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