PMID: 9546931Jan 1, 1996Paper

Prostanoid drug therapy for peripheral arterial occlusive disease--the European experience

Vascular Medicine
J A Dormandy

Abstract

The most serious threat to a claudicant is not the possible future need for a major amputation, but rather that the medium-term mortality is two to three times that of the general age-matched population. In patients with more severe disease in the legs, approximately 45% will have had a major amputation or be dead within a year of developing rest pain, ulcers or gangrene. These are the challenges for pharmacotherapy in peripheral arterial occlusive disease. In the short and medium term, pharmacotherapy can only have a significant effect by modifying the microcirculatory response to the low perfusion pressure caused by the arterial disease. The microcirculatory changes in the leg in severe leg ischaemia are ill understood, but theoretically a number of pharmacological effects could be beneficial. In practice, the only type of drugs widely tested clinically in severe leg ischaemia are prostacyclin and its analogues. In the last 12 years the results of properly controlled randomized trials involving patients with chronic limb ischaemia have been carried out in approximately 2000 patients in Europe. The largest number were entered into trials using the prostacyclin analogue iloprost. Some of these trials have shown a significant be...Continue Reading

References

Apr 1, 1991·European Journal of Vascular Surgery·J A Dormandy, G D Murray
May 1, 1991·The British Journal of Surgery·J D Holdsworth
Jan 1, 1993·Annals of Vascular Surgery·F C SmithC P Shearman
Dec 1, 1993·The British Journal of Surgery·A W BradburyC V Ruckley

❮ Previous
Next ❯

Citations

Jun 19, 2001·Cardiology in Review·M A Creager
Jan 11, 2018·The Cochrane Database of Systematic Reviews·Valeria ViettoAgustín Ciapponi
Oct 2, 2003·Vascular Medicine·Christian F A Kügler, Gottfried Rudofsky
Jan 22, 2010·The Cochrane Database of Systematic Reviews·Antonio J RuffoloAgustín Ciapponi
Mar 29, 2008·Vascular Medicine·Mark A CreagerWilliam R Hiatt
May 9, 2001·Current Treatment Options in Cardiovascular Medicine·David L. Dawson, Ryan T. Hagino
May 9, 2001·Current Treatment Options in Cardiovascular Medicine·Alan T. Hirsch, Laura M Reich
May 9, 2007·Current Treatment Options in Cardiovascular Medicine·David L Dawson, Joseph L Mills
Nov 7, 2003·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·J Vane, R E Corin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.