PMID: 3766758Oct 1, 1986Paper

Prostanoid mediation of pulmonary vascular response to acetylcholine in rabbits

The American Journal of Physiology
H A el Kashef, J D Catravas

Abstract

We studied the effects of acetylcholine (ACh) in the anesthetized, open-chest rabbit. ACh (5-20 nmol/kg), administered as a bolus into the right jugular vein, produced a dose-dependent increase in both pulmonary arterial pressure and pulmonary vascular resistance but a decrease in systemic arterial pressure and pulmonary blood flow. All these effects were prevented by atropine. Pretreatment with the phospholipase A2 inhibitor quinacrine reduced the pulmonary vascular responses to ACh without affecting systemic arterial pressure. Similarly, treatment with the cyclooxygenase inhibitors indomethacin or meclofenamate completely eliminated the pulmonary vascular response to ACh without affecting systemic arterial pressure or pulmonary blood flow. Treatment with the lipoxygenase inhibitor nordihydroguaiaretic acid, however, had no effect on the pulmonary or systemic vascular responses to ACh. Furthermore, administration of the thromboxane A2 synthetase inhibitor 7-(1-imidazolyl)-heptanoic acid or the thromboxane A2 receptor antagonist SQ 29,548 completely eliminated the pulmonary vascular responses to ACh without affecting systemic arterial pressure or pulmonary blood flow. Plasma levels of immunoreactive thromboxane B2 increased aft...Continue Reading

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