Prostanoid synthesis and vascular responses to exogenous arachidonic acid following cerebral ischemia in piglets

Prostaglandins
C W LefflerO Thelin

Abstract

In newborn pigs, cerebral ischemia abolishes both increased cerebral prostanoid production and cerebral vasodilation in response to hypercapnia and hypotension. Attenuation of prostaglandin endoperoxide synthase activity could account for the failure to increase prostanoid synthesis and loss of responses to these stimuli. To test this possibility, arachidonic acid (3, 6, or 30 micrograms/ml) was placed under cranial windows in newborn pigs that had been exposed to 20 min of cerebral ischemia. The conversion to prostanoids and pial arteriolar responses to the arachidonic acid were measured. At all three concentrations, arachidonic acid caused similar increases in pial arteriolar diameter in sham control piglets and piglets 1 hr postischemia. Topical arachidonic acid caused dose-dependent increases of PGE2 in cortical periarachnoid cerebral spinal fluid. 6-keto-PGF1 alpha and TXB2 only increased at the highest concentration of arachidonic acid (30 micrograms/ml). Cerebral ischemia did not decrease the conversion of any concentration of arachidonic acid to PGE2, 6-keto-PGF1 alpha, or TXB2. We conclude that ischemia and subsequent reperfusion do not result in inhibition of prostaglandin endoperoxide synthase in the newborn pig brai...Continue Reading

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Citations

Oct 24, 1998·Prostaglandins & Other Lipid Mediators·N ThrikawalaD W Busija
Jun 24, 1998·Brain Research. Developmental Brain Research·R DégìD W Busija
Sep 30, 1998·Journal of Neurotrauma·W M Armstead
Oct 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S Hyslop, G De Nucci
Sep 1, 1996·The Journal of Urology·J T DaleyI Saenz de Tejada
Jun 2, 2005·Pathophysiology : the Official Journal of the International Society for Pathophysiology·William M Armstead
Jan 22, 2008·The Journal of Pediatrics·Gilles CambonieJean-Charles Picaud
Jun 17, 1998·Stroke; a Journal of Cerebral Circulation·K OsukaJ Yoshida
Sep 14, 1999·The American Journal of Physiology·F DomokiD W Busija
Dec 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Amanda L Jagolino, William M Armstead
Jun 5, 1998·The American Journal of Physiology·I LahaieS Chemtob
Dec 18, 2002·Experimental Biology and Medicine·William M Armstead

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