Prostasomes are secreted from poorly differentiated cells of prostate cancer metastases

The Prostate
Göran SahlénB O Nilsson

Abstract

Prostasomes are small (40-500 nm), granule-like bodies, found in normal epithelial cells of the prostate and secreted into the prostate duct system. Also poorly differentiated prostate cancer cells are producing prostasomes, since we could isolate and purify prostasomes from vertebral metastases with biochemical methods. To find out whether these prostasomes are secreted into extracellular sites of the metastases, we used electron microscopy. Small biopsies from vertebral metastases of prostate cancer, taken directly from the operating field at surgery, were immediately fixated, embedded in plastic and processed for electron microscopy. We found that prostasomes could be identified extracellularly in the interstitial tissues as well as in the cytoplasm of the metastatic cells. We conclude that prostasomes produced by the cells of vertebral metastases of prostate cancer are distributed both intracellularly and extracellularly in the interstitial spaces of the tissue. Thus, prostasomes of metastases could perhaps be exploited as targets for immunodiagnosis and/or immunotherapy.

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Citations

May 11, 2011·Proceedings of the National Academy of Sciences of the United States of America·Gholamreza TavoosidanaMasood Kamali-Moghaddam
Oct 24, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Marian AalbertsWillem Stoorvogel
Apr 8, 2014·BioMed Research International·Ilaria Giusti, Vincenza Dolo
Jan 30, 2013·Biochimica Et Biophysica Acta·James Robert Krycer, Andrew John Brown
Aug 27, 2014·The Journal of Cell Biology·Laura CorriganClive Wilson
Mar 25, 2006·International Journal of Cancer. Journal International Du Cancer·Karl Göran RonquistAnders Larsson
Sep 19, 2006·BJU International·Anuj GoyalAlan J Cooper
Jan 15, 2009·The Prostate·K Göran RonquistAnders Larsson
Apr 2, 2016·The Journal of Clinical Investigation·Carla Zijlstra, Willem Stoorvogel
May 13, 2015·Prostate Cancer and Prostatic Diseases·S I BrettH S Leong
Aug 13, 2013·Biochimica Et Biophysica Acta·A BlokzijlM Kamali-Moghaddam
Jul 12, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Che-Ming LiuShian-Ying Sung
Dec 1, 2009·Upsala Journal of Medical Sciences·Göran SahlénGunnar Ronquist
Jan 16, 2007·The Prostate·Adil A BabikerKristina Nilsson Ekdahl
Jan 21, 2006·The Prostate·Adil A BabikerKristina Nilsson Ekdahl
Oct 11, 2007·Scandinavian Journal of Clinical and Laboratory Investigation·K G RonquistA Larsson
Oct 22, 2008·Scandinavian Journal of Urology and Nephrology·Gunnar RonquistTorsten Lindeborg
Jan 6, 2017·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A ValentinoC Rolfo
Nov 4, 2008·Scandinavian Journal of Urology and Nephrology·Alistair B StewartBashir A Lwaleed
Jun 29, 2018·Frontiers in Oncology·Virginie Vlaeminck-Guillem
Nov 14, 2021·Cell Communication and Signaling : CCS·Pia GiovannelliGabriella Castoria

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