Prostate cancer antigen 3 moderately improves diagnostic accuracy in Chinese patients undergoing first prostate biopsy

Asian Journal of Andrology
Fu-Bo WangYing-Hao Sun

Abstract

Prostate cancer antigen 3 (PCA3) is a biomarker for diagnosing prostate cancer (PCa) identified in the Caucasian population. We evaluated the effectiveness of urinary PCA3 in predicting the biopsy result in 500 men undergoing initial prostate biopsy. The predictive power of the PCA3 score was evaluated by the area under receiver operating characteristic (ROC) curve (AUC) and by decision curve analysis. PCA3 score sufficed to discriminate positive from negative prostate biopsy results but was not correlated with the aggressiveness of PCa. The ROC analysis showed a higher AUC for the PCA3 score than %fPSA (0.750 vs 0.622, P = 0.046) in patients with a PSA of 4.0-10.0 ng ml-1 , but the PCA3-based model is not significantly better than the base model. Decision curve analysis indicates the PCA3-based model was superior to the base model with a higher net benefit for almost all threshold probabilities, especially the threshold probabilities of 25%-40% in patients with a PSA of 4.0-10.0 ng ml-1 . However, the AUC of the PCA3 score (0.712) is not superior to %fPSA (0.698) or PSAD (0.773) in patients with a PSA >10.0 ng ml-1 . Our results confirmed that the RT-PCR-based PCA3 test moderately improved diagnostic accuracy in Chinese patien...Continue Reading

References

Jun 20, 2003·European Urology·Daphne HesselsJack A Schalken
May 28, 2004·The New England Journal of Medicine·Ian M ThompsonCharles A Coltman
Aug 22, 2006·The Prostate·Uta SchmidtAxel Meye
Nov 13, 2007·Clinical Biochemistry·Riina-Minna VäänänenKim Pettersson
Jul 8, 2008·European Urology·Alexander HaeseJack A Schalken
Aug 26, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andrew J VickersHans Lilja
Feb 9, 2011·Current Opinion in Urology·Monique J Roobol
Feb 22, 2011·International Journal of Urology : Official Journal of the Japanese Urological Association·Atsushi OchiaiZephyr Fors
Aug 30, 2011·European Urology·Marco AuprichHenk van der Poel
Mar 20, 2012·European Urology·Melissa M CenterFreddie Bray
Mar 19, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xavier FilellaWladimiro Jiménez
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Apr 15, 2014·Biochimica Et Biophysica Acta·Carsten StephanKlaus Jung

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Methods Mentioned

BETA
biopsy
biopsies
RNA-seq
Assay
PCR
cell collection

Software Mentioned

MedCalc
StepOne
Stata

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