Prostate cancer cells use genetic and epigenetic mechanisms for progression to androgen independence

Genes, Chromosomes & Cancer
Horacio MurilloDonald J Tindall

Abstract

Studies on the genetic basis of prostate cancer (PCa) have lead to mixed results with the only consensus being that PCa is a complex disease. Our goal was to gain insight into potential events involved in the acquisition of the androgen-refractory phenotype in PCa cells regardless of DNA-change dependence. To this end, we examined two LNCaP PCa cell line models of progression-one developed in vivo and one developed in vitro-using molecular cytogenetic and microarray gene expression analyses and extended this investigation of specific events into PCa tumors. The chromosomal changes observed in both in vivo and in vitro androgen-independent cell lines are similar to those seen in PCa during tumor progression. Correspondingly, gene expression analysis showed significant heterogeneity in the genes expressed among androgen-independent cells, but with some common gene expression changes that correlated with the acquired androgen-independent phenotype. Thus, growth conditions under which the cells progress appeared to impact the mechanisms used for progression, albeit within tumor-type-specific pathways. Our findings suggest that a dynamic and adaptable combination of epigenetic and DNA-change-dependent events can be used by PCa cells...Continue Reading

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Citations

Aug 30, 2011·Cancer Genetics·Sonata JarmalaiteKirsti Husgafvel-Pursiainen
Apr 20, 2011·Biochemical and Biophysical Research Communications·Takahiro FujimotoSenji Shirasawa
Apr 29, 2008·The Journal of Pharmacology and Experimental Therapeutics·Bin SunBrian S Cummings

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