Prostate cancer detected by uPM3: radical prostatectomy findings

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
David G BostwickMichael Marberger

Abstract

uPM3 is the first urine-based genetic test that is highly specific for detecting prostate cancer. The histopathologic characteristics of uPM3-detected cancer in radical prostatectomy specimens have not been previously described. We evaluated a consecutive series of radical prostatectomies to determine the extent, zonal distribution and other features of prostate cancer following uPM3 detection. A total of 24 whole-mounted, totally embedded radical prostatectomy specimens were evaluated. All patients had clinically localized cancer and none received preoperative therapy. Zonal location of cancer, distance to the urethra, cancer volume, Gleason grade and multicentricity were recorded; volume of cancer was measured using the grid-counting method. Patients ranged in age from 43 to 75 years (mean 65 years). In 21/24 cases, cancer involved the transition and peripheral zones and was multicentric (87%). Mean cancer volume was 3.96 cm3 (range 0.08-16.86 cm3). Mean distance to the urethra was 0.50 cm for the closest cancer and 0.61 cm for the most distant cancer. Mean Gleason score was 7 (range 5-9); pathologic stage was pT2 for 17 cases and pT3 for seven cases. The uPM3 is an independent and specific biomarker that detects prostate can...Continue Reading

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Apr 2, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Lori E EichelbergerLiang Cheng

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Citations

Sep 18, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ion PopaBernard Têtu
Jun 28, 2007·BJU International·Michael Marberger
Aug 30, 2011·European Urology·Marco AuprichHenk van der Poel
Aug 14, 2010·Primary Care·Bob DjavanHerbert Lepor
Jul 10, 2009·Urology·Virginie Vlaeminck-GuillemPhilippe Paparel
Jul 19, 2018·Expert Review of Anticancer Therapy·Guillaume Ploussard, Alexandre de la Taille
Aug 18, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xiao-Song WangWei-Feng Chen

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