Prostate cancer detection among men with prostate specific antigen levels of 2.5 to 4.0 ng/ml in a Japanese urological referral population

The Journal of Urology
Takashi KobayashiYoshihiro Ide

Abstract

Prostate cancer detection at levels of 2.5 to 4.0 ng/ml in a Japanese urological referral population has not been elucidated. The purpose of this study is to investigate the cancer detection rate and clinical relevance of prostate cancer in this PSA range. All urological patients 70 years or younger tested for prostate cancer were studied. There were 550, 97, 112 and 52 patients with a PSA of less than 2.5, 2.5 to 4.0, 4.1 to 10.0 and more than 10.0 ng/ml, respectively. Transrectal 10-core prostate biopsy was performed in 80 (82%) of the 97 patients with a PSA of 2.5 to 4.0 ng/ml and 102 (91%) of the 112 patients with a PSA of 4.1 to 10.0 ng/ml. Cancer detection rates in patients who underwent biopsy were 26.3% and 34.3% at PSA levels 2.5 to 4.0 and 4.1 to 10.0 ng/ml, respectively. High grade cancers with Gleason score 7 or more were found in 19.0% and 22.9% of patients with cancer with PSA 2.5 to 4.0 and 4.1 to 10.0 ng/ml, respectively. No significant difference was found between the 2 groups in pathological findings on biopsy, including percent positive cores (16.7% vs 20.0%, p = 0.10), maximum cancer length (25.0% vs 30.0%, p = 0.28) and maximum percent cancer length (2.0 vs 3.0 mm, p = 0.17). Japanese urological referral pa...Continue Reading

References

Feb 2, 1994·JAMA : the Journal of the American Medical Association·J I EpsteinC B Brendler
Aug 18, 1993·JAMA : the Journal of the American Medical Association·J E OesterlingM M Lieber
Aug 25, 1993·JAMA : the Journal of the American Medical Association·W J CatalonaJ W Basler
Jun 18, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chaundre K CrossAnthony V D'Amico
May 28, 2004·The New England Journal of Medicine·Ian M ThompsonCharles A Coltman
Jul 13, 2004·The New England Journal of Medicine·Anthony V D'AmicoWilliam J Catalona
Nov 13, 2004·The Journal of Urology·William G NelsonWilliam B Isaacs
Sep 22, 2005·International Journal of Urology : Official Journal of the Japanese Urological Association·Takashi KobayashiToshiyuki Kamoto

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Citations

May 20, 2009·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M BonetC Bouchardy
Feb 7, 2012·Asian Journal of Andrology·Shu-Jie XiaQi Jiang
Jan 15, 2011·Japanese Journal of Clinical Oncology·Kazuhiro NagaoHideyasu Matsuyama
Apr 18, 2009·The Journal of Urology·Joshua J MeeksWilliam J Catalona
May 22, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Seyyed Yousof HosseiniMohammah Reza Safarinejad

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