PMID: 11342887May 9, 2001Paper

Prostate cancer detection in men with prior high grade prostatic intraepithelial neoplasia or atypical prostate biopsy

The Journal of Urology
S ParkP R Carroll

Abstract

We used clinical variables to predict prostate cancer detection on re-biopsy among patients diagnosed with high grade prostatic intraepithelial neoplasia (PIN) or atypia on initial prostate biopsy. A total of 45 men with atypia and 43 with high grade PIN were eligible for our study. Clinical variables were tested with univariate and multivariate logistic regression to predict who would have cancer on re-biopsy. We also calculated the odds of detecting cancer with various repeat sampling strategies and determined whether the location of initial atypia or high grade PIN is correlated to that of cancer on re-biopsy. Of the patients in the atypia and high grade PIN groups 51% had cancer on re-biopsy. Cancer was diagnosed significantly earlier in the high grade PIN than in the atypia cohort (average 7.5 versus 22.9 months, respectively, p = 0.005). Multivariate logistic modeling showed that digital rectal examination and patient age were independent predictors of cancer in atypia, whereas no variables were significantly predictive for high grade PIN. Of cancers in the atypia and high grade PIN 65% and 74%, respectively, would have been detected if re-biopsy was focused only at the initial site of disease. Men with atypia or high gra...Continue Reading

References

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Citations

Jun 27, 2002·Current Urology Reports·Timothy Donahue, Judd Moul
Jul 15, 2003·Urologic Oncology·Mingxin CheDavid Grignon
Jul 15, 2003·Urologic Oncology·Maxwell V MengGary D Grossfeld
Aug 13, 2005·The American Journal of Surgical Pathology·Cory SchlesingerKenneth A Iczkowski
Sep 8, 2006·Ultrasound Quarterly·Hossein Sadeghi-NejadVikram Dogra
Apr 7, 2010·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Assaad El-Hakim, Sabri Moussa
Jan 4, 2012·Histopathology·David G Bostwick, Liang Cheng
Mar 1, 2006·Urology·J Kellogg Parsons, Alan W Partin
Jan 20, 2015·The Prostate·Ryan P DorinJoseph R Wagner
Dec 3, 2008·Virchows Archiv : an International Journal of Pathology·Jonathan I Epstein
May 26, 2004·International Journal of Urology : Official Journal of the Japanese Urological Association·Takashi KobayashiYoshihiro Ide
Jun 7, 2012·Korean journal of urology·Joseph C KlinkEric A Klein
Aug 8, 2006·The Journal of Urology·Brent V YankeIvan Colon
Aug 19, 2008·The Journal of Urology·Nelly TanJ Stephen Jones
Apr 14, 2012·The Journal of Urology·Ryan P KoppChristopher J Kane
Jan 12, 2005·The Journal of Urology·Brent V YankeMichael W Kattan
Mar 3, 2004·Prostate Cancer and Prostatic Diseases·J E Busby, C P Evans
Jan 24, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·David G Bostwick, Junqi Qian
Sep 13, 2003·Prostate Cancer and Prostatic Diseases·R DamianoM D'Armiento
Oct 3, 2007·Prostate Cancer and Prostatic Diseases·G Godoy, S S Taneja
Sep 1, 2017·Nature Reviews. Urology·Jeffrey J TosoianJonathan I Epstein
Aug 23, 2017·Critical Reviews in Clinical Laboratory Sciences·Francesca SanguedolceLuigi Cormio

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