Prostate Cancer Germline Variations and Implications for Screening and Treatment

Cold Spring Harbor Perspectives in Medicine
Alexander DiasRos A Eeles

Abstract

Prostate cancer (PCa) is a highly heritable disease, and rapid evolution of sequencing technologies has enabled marked progression of our understanding of its genetic inheritance. A complex polygenic model that involves common low-penetrance susceptibility alleles causing individually small but cumulatively significant risk and rarer genetic variants causing greater risk represent the current most accepted model. Through genome-wide association studies, more than 100 single-nucleotide polymorphisms (SNPs) associated with PCa risk have been identified. Consistent reports have identified germline mutations in the genes BRCA1, BRCA2, MMR, HOXB13, CHEK2, and NBS1 as conferring moderate risks, with some leading to a more aggressive disease behavior. Considering this knowledge, several research strategies have been developed to determine whether targeted prostate screening using genetic information can overcome the limitations of population-based prostate-specific antigen (PSA) screening. Germline DNA-repair mutations are more frequent in men with metastatic disease than previously thought, and these patients have a more favorable response to therapy with poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors. Genomic ...Continue Reading

References

Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·B S CarterP C Walsh
Aug 1, 1995·Nature Medicine·K R MonroeB E Henderson
Oct 27, 1997·American Journal of Epidemiology·H GrönbergL Iselius
Jun 19, 1998·American Journal of Human Genetics·P BerthonO Cussenot
Jul 15, 1998·International Journal of Cancer. Journal International Du Cancer·K Hemminki, P Vaittinen
May 23, 2000·American Journal of Human Genetics·R BerryD J Schaid
Nov 9, 2000·BJU International·M K KarayiA F Markham
Dec 6, 2000·British Journal of Cancer·R Singh, UNKNOWN ACTANE consortium. Anglo, Canada, Texas, Australia, Norway, EU Biomed
Feb 15, 2001·American Journal of Human Genetics·D ThompsonUNKNOWN Breast Cancer Linkage Consortium
Feb 15, 2001·Nature Genetics·S V TavtigianL A Cannon-Albright
Apr 20, 2001·American Journal of Human Genetics·J CuiG G Giles
Dec 6, 2001·Trends in Molecular Medicine·M Futaki, J M Liu
Dec 6, 2001·Nature Reviews. Molecular Cell Biology·J BartekJ Lukas
Feb 8, 2002·Cell·Ashok R Venkitaraman
Sep 19, 2002·Journal of the National Cancer Institute·Deborah ThompsonUNKNOWN Breast Cancer Linkage Consortium
Dec 24, 2002·Prostate Cancer and Prostatic Diseases·R A Eeles
Jun 5, 2003·BJU International·L E Johns, R S Houlston
Jun 26, 2003·The New England Journal of Medicine·Ian M ThompsonCharles A Coltman
May 10, 2006·Nature Genetics·Laufey T AmundadottirKari Stefansson
Sep 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Matthew L FreedmanDavid Reich
Apr 3, 2007·Nature Genetics·Meredith YeagerGilles Thomas
Apr 11, 2007·BJU International·Anita V MitraUNKNOWN IMPACT Steering Committee and Collaborators
Jun 15, 2007·Journal of the National Cancer Institute·Laufey TryggvadóttirHrafn Tulinius
Oct 16, 2007·BMC Medical Genetics·Joanne M MurabitoShih-Jen Hwang
Jan 31, 2008·European Journal of Human Genetics : EJHG·Iona ChengJohn S Witte
Feb 12, 2008·Nature Genetics·Gilles ThomasStephen J Chanock
Feb 12, 2008·Nature Genetics·Rosalind A EelesDouglas F Easton
Feb 12, 2008·Nature Genetics·Julius GudmundssonKari Stefansson
Mar 20, 2008·JAMA : the Journal of the American Medical Association·Thomas A Pearson, Teri A Manolio
Jun 26, 2008·British Journal of Cancer·S A NarodChristina Bellati
Aug 19, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Zsofia Kote-JaraiRosalind A Eeles
Sep 19, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Stefanie D Hueber, Ingrid Lohmann
Dec 4, 2008·Asian Journal of Andrology·Michelle GuyRosalind A Eeles
Jan 2, 2009·Cancer Research·Jielin SunBao-Li Chang
Sep 22, 2009·Nature Genetics·Ali Amin Al OlamaDouglas F Easton
Nov 18, 2009·Molecular Cell·John D NorrisDonald P McDonnell

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Citations

Apr 25, 2018·International Journal of Molecular Sciences·Shyh-Han TanShiv Srivastava
Apr 28, 2020·International Journal of Cancer. Journal International Du Cancer·Tú Nguyen-DumontMelissa C Southey
Dec 13, 2018·Nature Reviews. Cancer·Samaneh FarashiJyotsna Batra
May 1, 2021·International Journal of Molecular Sciences·Maria Teresa VietriAnna Maria Molinari

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