Prostate cancer: is inapparent tumor at endorectal MR and MR spectroscopic imaging a favorable prognostic finding in patients who select active surveillance?

Radiology
Alvin R CabreraJohn Kurhanewicz

Abstract

To retrospectively determine whether inapparent tumor at endorectal magnetic resonance (MR) imaging and MR spectroscopic imaging is a favorable prognostic finding in prostate cancer patients who select active surveillance for management. Committee on Human Research approval was obtained and compliance with HIPAA regulations was observed, with waiver of requirement for written consent. Ninety-two men (mean age, 64 years; range, 43-85 years) were retrospectively identified who had biopsy-proved prostate cancer, who had undergone baseline endorectal MR imaging and MR spectroscopic imaging, and who had selected active surveillance for management. Their mean baseline serum prostate-specific antigen (PSA) level was 5.5 ng/mL, and the median Gleason score was 6. Two readers with 10 and 3 years of experience independently reviewed all MR images and determined whether tumor was apparent on the basis of evaluation of established morphologic and metabolic findings. Another investigator compiled data about baseline clinical stage, biopsy findings, and serum PSA measurements. Multiple logistic regression analysis was used to investigate the relationship between the clinical parameters and tumor apparency at MR imaging and the biochemical ou...Continue Reading

References

Sep 1, 1995·Clinical Radiology·R A Huch BöniG P Krestin
Jan 22, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R G MalesJ Kurhanewicz
Dec 18, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A A SchrickerD B Vigneron
Feb 10, 2004·The Journal of Urology·Hongyan WuDouglas Soderdahl
Apr 21, 2005·BJU International·Claire HardieDavid Dearnaley

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Citations

Jun 12, 2013·World Journal of Urology·Matthias C RoethkeDavid Schilling
Sep 21, 2011·Radiology·Caroline M A HoeksJurgen J Fütterer
Jul 11, 2009·Expert Review of Anticancer Therapy·Jurgen J FüttererStijn Twpj Heijmijnk
Feb 5, 2013·Journal of the American College of Radiology : JACR·Steven C EberhardtSeth A Rosenthal
Jun 23, 2011·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·F StaermanUNKNOWN CCAFU
Apr 13, 2011·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·E XylinasL Salomon
Feb 8, 2011·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·F LuyckxJ Rigaud
Oct 6, 2009·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·V AzancotM Zerbib
Oct 30, 2013·BJU International·James ThompsonUNKNOWN USANZ
Jun 14, 2013·NMR in Biomedicine·Thiele KobusArend Heerschap
Oct 12, 2010·Nature Reviews. Urology·Orit RazNathan Lawrentschuk
Sep 22, 2018·Current Opinion in Urology·Jared S WinokerArdeshir R Rastinehad

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