Prostate cancer. Multidisciplinary approach: a key to success

Critical Reviews in Oncology/hematology
C MontagutJ Bellmunt

Abstract

Diagnosis and treatment of prostate cancer has improved in the last few years, in part due to a multidisciplinary approach between urologists, oncologists, radiotherapists, radiologists, pathologists, basic and translational researchers for a successful management. The TAX 327 study is the paradigm of a smooth communication between expert physicians that led to the approval of docetaxel in metastatic hormone-resistant prostate cancer (HRPC). Survival benefit with docetaxel in HRPC was confirmed in an updated survival analysis reported this year. A nomogram to predict survival in metastatic HRPC treated with chemotherapy was established based on the TAX 327 study. Unfortunately in early prostate cancer, some of the phase III clinical trials with chemotherapy had to be closed due to lack of sufficient accrual, due to, at least in part, an unsuccessful collaboration between urologists, medical oncologists and radiotherapists. In earlier phases of prostate cancer, a successful multidisciplinary approach has led to important advances in genomics, biomarkers and imaging techniques that have created big excitement for future improvements in the management of prostate cancer. An example is the validation of novel molecular diagnosis te...Continue Reading

References

Oct 8, 2004·The New England Journal of Medicine·Ian F TannockUNKNOWN TAX 327 Investigators
Mar 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan GoodinRobert S DiPaola
Oct 29, 2005·Science·Scott A TomlinsArul M Chinnaiyan
Mar 10, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L Mileshkin, J Zalcberg
Feb 10, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Martijn P M Q van GilsJack A Schalken
Apr 18, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A OttaianoM Caraglia
Sep 6, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daphne HesselsJack A Schalken
Nov 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andrew J ArmstrongMario Eisenberger
Dec 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ultan McDermottJeffrey Settleman
Dec 15, 2007·Genes & Development·Sreenath V Sharma, Jeffrey Settleman
Jan 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dominik R BertholdIan F Tannock
Feb 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kim N ChiElizabeth Eisenhauer

❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Related Papers

The Medical Journal of Australia
M A Rosenthal
Wiener klinische Wochenschrift
Michael RauchenwaldMichael Krainer
Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Asunción Hervás MorónEduardo Lobo Martínez
© 2022 Meta ULC. All rights reserved