Prostate cancer. Part 2: Review of the various tumor grading systems over the years 1966-2015 and future perspectives of the new grading of the International Society of Urological Pathology (ISUP)

Der Pathologe
Burkhard HelpapGlen Kristiansen

Abstract

The continued development of methods in needle biopsies and radical prostatectomy for treatment of prostate cancer has given special emphasis to the question of the prognostic relevance of the various systems of grading. The classical purely histological grading system of Gleason has been modified several times in the past decades and cleared the way for a new grading system by the prognostic grading of Epstein. Assessment of the old and also modified combined histological and cytological grading of Mostofi, the World health Organization (WHO) and the urologic-pathological working group of prostate cancer in connection with the Gleason grading (combined Gleason-Helpap grading), has led to considerably improved rates of concordance between biopsy and radical prostatectomy and to improved estimations of prognosis beside its contribution to the development of a more practicable grading system for clinical use.

References

Aug 13, 2005·The American Journal of Surgical Pathology·Jonathan I EpsteinUNKNOWN ISUP Grading Committee
Nov 9, 2006·Virchows Archiv : an International Journal of Pathology·Burkhard Helpap, Lars Egevad
Dec 17, 2009·The Journal of Urology·Jonathan I Epstein
Nov 23, 2011·International Journal of Urology : Official Journal of the Japanese Urological Association·Burkhard Helpap, Jens Köllermann
Mar 8, 2013·BJU International·Phillip M PierorazioJonathan I Epstein
Oct 16, 2014·Virchows Archiv : an International Journal of Pathology·Rodolfo MontironiUNKNOWN Association of Directors of Anatomic and Surgical Pathology
Sep 9, 2015·Urologia Internationalis·Burkhard HelpapHans-Helge Seifert
Nov 14, 2015·Pathology Oncology Research : POR·Burkhard HelpapHans-Helge Seifert
Jan 27, 2016·Der Pathologe·G KristiansenUNKNOWN Graduierungskommittee

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Citations

Jul 10, 2016·Der Pathologe·G KristiansenB Helpap

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