Prostate cancer risk prediction using the novel versions of the European Randomised Study for Screening of Prostate Cancer (ERSPC) and Prostate Cancer Prevention Trial (PCPT) risk calculators: independent validation and comparison in a contemporary European cohort

BJU International
Cédric PoyetThomas Hermanns

Abstract

To externally validate and compare the two novel versions of the European Randomised Study for Screening of Prostate Cancer (ERSPC)-prostate cancer risk calculator (RC) and Prostate Cancer Prevention Trial (PCPT)-RC. All men who underwent a transrectal prostate biopsy in a European tertiary care centre between 2004 and 2012 were retrospectively identified. The probability of detecting prostate cancer and significant cancer (Gleason score ≥7) was calculated for each man using the novel versions of the ERSPC-RC (DRE-based version 3/4) and the PCPT-RC (version 2.0) and compared with biopsy results. Calibration and discrimination were assessed using the calibration slope method and the area under the receiver operating characteristic curve (AUC), respectively. Additionally, decision curve analyses were performed. Of 1 996 men, 483 (24%) were diagnosed with prostate cancer and 226 (11%) with significant prostate cancer. Calibration of the two RCs was comparable, although the PCPT-RC was slightly superior in the higher risk prediction range for any and significant prostate cancer. Discrimination of the ERSPC- and PCPT-RC was comparable for any prostate cancer (AUCs 0.65 vs 0.66), while the ERSPC-RC was somewhat better for significant...Continue Reading

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Citations

Feb 16, 2016·BJU International·Dara J Lundon
Jul 26, 2016·Frontiers in Oncology·F Roy MacKintoshThomas B Neville
Jun 27, 2017·Current Opinion in Urology·James T Kearns, Daniel W Lin
Jun 22, 2016·Current Opinion in Urology·Sigrid V Carlsson, Monique J Roobol
May 13, 2020·International Journal of Cancer. Journal International Du Cancer·Sebastiaan Remmers, Monique J Roobol
Sep 28, 2016·International Journal of Clinical Practice·Talisa RossProkar Dasgupta
Oct 19, 2016·BJU International·Cédric Poyet, Thomas Hermanns
Sep 10, 2020·Postgraduate Medicine·William W French, Eric M Wallen
May 22, 2020·World Journal of Urology·I- Hsuan Alan ChenPrasanna Sooriakumaran
Aug 12, 2018·Advances in Therapy·Samuel W D MerrielWillie Hamilton
Dec 19, 2020·Journal of Medical Internet Research·I-Hsuan Alan ChenManish Chand
Mar 24, 2021·Archivio italiano di urologia, andrologia : organo ufficiale [di] Società italiana di ecografia urologica e nefrologica·Andrea B GalosiLucio Dell'Atti
Jul 17, 2021·Prostate Cancer and Prostatic Diseases·Peter Ka-Fung ChiuJeremy Yuen-Chun Teoh
Sep 1, 2021·Annals of Clinical Biochemistry·Manuel M GarridoJoão T Guimarães
Sep 4, 2021·JMIR Cancer·Antonio Bandala-JacquesNancy Reynoso-Noverón

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