Prostate cancer risk: the significance of differences in age related changes in serum conjugated and unconjugated steroid hormone concentrations between Arab and Caucasian men

International Urology and Nephrology
E O KehindeT Fatinikun

Abstract

Factors responsible for the low incidence of clinical prostate cancer (3-8/100,000 men/year) in the Arab population remain unclear, but may be related to changes in steroid hormone metabolism. We compared the levels of serum conjugated and unconjugated steroids between Arab and Caucasian populations, to determine if these can provide a rational explanation for differences in incidence of prostate cancer between the two populations. Venous blood samples were obtained from 329 unselected apparently healthy indigenous Arab men (Kuwaitis and Omanis) aged 15-80 years. Samples were also obtained from similar Arab men with newly diagnosed prostate cancer or benign prostatic hyperplasia (BPH). The samples were taken between 8:00 am and 12:00 noon. Serum levels of total testosterone, (TT), sex hormone binding globulin (SHBG), free androgen index (FAI); adrenal C19-steroids, dehydroepiandrosterone sulphate (DHEAS) and androstenedione (ADT) were determined using Immulite kits (Diagnostic Systems Laboratories Inc, Webster Texas, USA). The results obtained in Arab men were compared with those reported for similarly aged Chinese, German and White USA men. In all four ethnic groups, median TT and FAI declined with age, while SHBG increased wi...Continue Reading

References

Jul 1, 1977·The Journal of Urology·J K SmolevW W Scott
Jan 1, 1991·Epidemiologic Reviews·A M Nomura, L N Kolonel
Jun 1, 1991·The Journal of Clinical Endocrinology and Metabolism·D P LookingbillR J Santen
Nov 1, 1991·The Journal of Nutrition·E G MacEwen, I D Kurzman
Nov 1, 1987·Metabolism: Clinical and Experimental·R H RaoG S Spathis
Jun 1, 1966·The Journal of Clinical Endocrinology and Metabolism·T KobayashiC W Lloyd
Aug 21, 1996·Journal of the National Cancer Institute·A W Hsing
Aug 21, 1996·Journal of the National Cancer Institute·P H GannM J Stampfer
Apr 1, 1997·The Journal of Urology·D N Osegbe
Feb 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T ShaneyfeltC S Mantzoros
Apr 19, 2003·World Journal of Urology·Ronald Lieberman
Aug 28, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Martin W ElmlingerWerner Kuehnel

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Citations

Oct 16, 2010·Cancer Research·Nuria Coll BastusYong-Jie Lu
Aug 27, 2010·Annals of the New York Academy of Sciences·Richard G Bribiescas
Jan 21, 2010·American Journal of Human Biology : the Official Journal of the Human Biology Council·Louis Calistro Alvarado
Jul 1, 2015·American Journal of Physical Anthropology·Louis Calistro AlvaradoGrazyna Jasienska
Jun 27, 2008·Indian Journal of Pediatrics·Utkarsh KohliS K Kabra
Sep 19, 2009·Tropical Doctor·Alain BenoisHervé Sergent

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