Prostate cancer screening, changing age-specific incidence trends and implications on familial risk

International Journal of Cancer. Journal International Du Cancer
Kari HemminkiJusto L Bermejo

Abstract

The incidence of prostate cancer has increased markedly during the past half century. We used the data from the Swedish Cancer Registry to follow the incidence trends and age-specific incidence up to 2002. Two different patterns in the age-incidence relationships were noted. The first one, prevailing until about 1995, was characterized by a preferential increase in incidence in men older than 70 years. In the second pattern, the increase extended preferentially to younger age groups, and it coincided with an introduction of opportunistic prostate specific antigen (PSA) screening, which was the probable cause of the large upward shift in the incidence between 1998 and 2000. The possible effects of diagnostic methods on familial risk estimates were tested by comparing age and calendar time differences among brothers who were diagnosed with prostate cancer, retrieved from the Swedish Family-Cancer Database. The 2 distributions were very different according to the Wilcoxon rank test (p < 0.0001). The data suggest that a diagnosis of prostate cancer in 1 brother leads to an early diagnosis in a second brother. The data are probably explained by the healthy brother seeking medical advice upon diagnosis in another brother. This effect...Continue Reading

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Citations

Oct 12, 2011·Der Radiologe·N Becker
Nov 26, 2011·World Journal of Urology·Kari Hemminki
Jan 12, 2013·World Journal of Urology·Kari HemminkiSeyed Mohsen Mousavi
Nov 3, 2005·Journal of the National Cancer Institute·J Lorenzo Bermejo, Kari Hemminki
Jun 7, 2007·Journal of the National Cancer Institute·Justo Lorenzo BermejoKari Hemminki
Aug 21, 2010·Journal of the National Cancer Institute·Ola BrattPär Stattin
Jan 1, 2006·Hereditary Cancer in Clinical Practice·Kari HemminkiJusto Lorenzo Bermejo
Jan 25, 2011·The Oncologist·Matias RiihimäkiKari Hemminki
Apr 8, 2014·BioMed Research International·Ilaria Giusti, Vincenza Dolo
Apr 7, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A BrandtK Hemminki
Sep 30, 2010·Acta Oncologica·Giuseppe Colloca, Antonella Venturino
Dec 12, 2012·The Journal of Urology·Xiangdong LiuKari Hemminki
Jul 25, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Joaquim BellmuntXavier Castells
Aug 11, 2015·Scientific Reports·C FrankK Hemminki
May 10, 2005·International Journal of Cancer. Journal International Du Cancer·Kari Hemminki, Justo Lorenzo Bermejo
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Nov 27, 2009·The Oncologist·Andreas BrandtKari Hemminki
Nov 9, 2012·The American Journal of Clinical Nutrition·Isabel DrakeElisabet Wirfält
Jan 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A BrandtK Hemminki

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