Prostate cancer, tumor immunity and a renewed sense of optimism in immunotherapy

Cancer Immunology, Immunotherapy : CII
Nicolò Rigamonti, Matteo Bellone

Abstract

The recent FDA approval of the first therapeutic vaccine against prostate cancer has revitalized the public interest in the fields of cancer immunology and immunotherapy. Yet, clinical results are modest. A reason for this limited success may reside in the capacity of the tumor to convert inflammation in a tumor-promoting condition and eventually escape immune surveillance. Here we present the main known interactions between the prostate tumor and the immune system, showing how the malignancy can dodge the immune system by also exerting several immunosuppressive mechanisms. We also discuss experimental and clinical strategies proposed to counteract cancer immune evasion and emphasize the importance of implementing appropriate murine models like the transgenic adenocarcinoma of the mouse prostate model for investigating the biology of prostate cancer and novel immunotherapy approaches against it.

References

Jun 1, 1985·The Journal of Urology·M WirthR Ackermann
Feb 1, 1995·The Journal of Experimental Medicine·L PialiR H Gisler
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·N M GreenbergJ M Rosen
Jan 17, 1995·International Journal of Cancer. Journal International Du Cancer·S A BirkelandL Frödin
Mar 22, 1996·Science·D R LeachJ P Allison
Nov 14, 1997·Immunity·C B Thompson, J P Allison
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·V GrohT Spies
Feb 27, 2001·Nature Immunology·Y LatchmanG J Freeman
Jun 16, 2001·Seminars in Cancer Biology·W J HussN M Greenberg
Sep 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S M TahirM A Exley
Jun 5, 2002·Nature Reviews. Cancer·Chris Boshoff, Robin Weiss
Oct 31, 2002·Nature Immunology·Gavin P DunnRobert D Schreiber
Dec 14, 2002·Human Immunology·Hubertus HochreinHermann Wagner
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Apr 6, 1957·British Medical Journal·M BURNET
Mar 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shahrokh F ShariatKevin M Slawin
May 19, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Bertram L KasiskeChangchun Wang
Oct 8, 2004·The New England Journal of Medicine·Ian F TannockUNKNOWN TAX 327 Investigators
Dec 2, 2004·Nature Reviews. Immunology·Dmitry Gabrilovich
Apr 13, 2005·The Journal of Experimental Medicine·Vincenzo BronteAntonella Viola
Jun 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Boris BienvenuBruno Lucas
Oct 29, 2005·Science·Scott A TomlinsArul M Chinnaiyan
Dec 20, 2005·Cancer Immunology, Immunotherapy : CII·Ashley M Miller, Pavel Pisa
Feb 1, 2006·The British Journal of Dermatology·F J MoloneyG M Murphy
Apr 26, 2006·Molecular Carcinogenesis·Rana P Singh, Rajesh Agarwal
Jun 24, 2006·Nature Reviews. Cancer·Brian Bierie, Harold L Moses

❮ Previous
Next ❯

Citations

Jun 28, 2012·Cancer Immunology, Immunotherapy : CII·Mostafa GhaneiAmin Saburi
Jun 29, 2012·Cancer Immunology, Immunotherapy : CII·Matteo Bellone, Nicolò Rigamonti
Apr 18, 2013·Cancer Immunology, Immunotherapy : CII·Daniela FenoglioGilberto Filaci
Oct 19, 2013·Cancer Immunology, Immunotherapy : CII·Giorgio MauriMario Paolo Colombo
May 21, 2014·Proceedings of the National Academy of Sciences of the United States of America·Olivia TwuPatricia J Johnson
Mar 19, 2013·Expert Review of Vaccines·Agnieszka MichaelHardev Pandha
Mar 2, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Angela Rita EliaMatteo Bellone
Nov 21, 2017·Cancer Letters·Sanjay KumarManoj Mishra

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Related Papers

Journal of Mammary Gland Biology and Neoplasia
Tim Kees, Mikala Egeblad
Molecular and Cellular Endocrinology
Xinguo Jiang, David J Shapiro
Pathology, Research and Practice
Neel SenguptaAndrew R Silver
Seminars in Immunology
Ruben PioJohn D Lambris
© 2022 Meta ULC. All rights reserved