Prostate cancers diagnosed at repeat biopsy are smaller and less likely to be high grade

The Journal of Urology
Nelly TanJ Stephen Jones

Abstract

We investigated whether prostate cancer diagnosed on initial prostate biopsy had worse pathological outcomes compared to that diagnosed on repeat prostate biopsy. We reviewed 905 newly diagnosed prostate cancer cases from 2000 to 2007. Patients were stratified by the number of previous biopsies, including the initial biopsy in 690, and 1 and 2 or greater negative previous biopsies in 142 and 73, respectively. We analyzed Gleason sum, number of cores taken, percent of positive cores and bilaterality of prostate cancer. Clinically insignificant cancers were defined according to prostate specific antigen density 0.4 ng/ml or less, 3 or fewer positive cores, 50% or less of maximum cancer in any core and Gleason sum 6 or less. Prostate cancer was diagnosed in 57%, 23% and 21% of cases in the initial, and 1 and 2 or greater negative previous biopsies groups, respectively. Initial prostate biopsy showed a higher number and percent of positive cores, and the maximum percent of prostate cancer involved in a core. However, the Gleason pattern distribution differed significantly in the 3 groups with the highest percent (14%) of Gleason sum 8 or greater in the subset with 2 or greater negative previous biopsies (p <0.01). On multivariate a...Continue Reading

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Citations

Jan 19, 2012·International Urology and Nephrology·Omer Gokhan DoluogluMesut Cetinkaya
Oct 18, 2012·Current Urology Reports·Ryan K Berglund, J Stephen Jones
Dec 4, 2008·Asian Journal of Andrology·Nigel Borley, Mark R Feneley
Aug 14, 2009·Japanese Journal of Clinical Oncology·Masashi ShimboJun Shimazaki
Mar 13, 2010·Future Oncology·Giovanni LughezzaniPierre I Karakiewicz
Jun 9, 2014·World Journal of Urology·Vincenzo ScattoniFrancesco Montorsi
Nov 5, 2013·The Urologic Clinics of North America·Mohamed T Ismail, Leonard G Gomella
Apr 14, 2012·The Journal of Urology·Ryan P KoppChristopher J Kane
May 17, 2011·The Journal of Urology·Nelly TanJ Stephen Jones
Jun 23, 2011·International Journal of Urology : Official Journal of the Japanese Urological Association·Osama M Zaytoun, J Stephen Jones
Mar 16, 2012·BJU International·Osama M ZaytounJ Stephen Jones
Jul 15, 2015·Nature Reviews. Urology·Michael L BluteDavid F Jarrard
Dec 3, 2014·The Journal of Urology·Nitya E AbrahamSamir S Taneja
Oct 19, 2016·The Journal of Urology
Jun 22, 2013·Korean journal of urology·Seung Je LeeKwangsung Park
Jun 18, 2016·Current Opinion in Urology·Marlon PereraNathan Lawrentschuk

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