PMID: 20126847Feb 4, 2010Paper

Prostate carcinoma and testosterone: risks and controversies

Arquivos brasileiros de endocrinologia e metabologia
Ernani Luis Rhoden, Márcio Augusto Averbeck

Abstract

Hypogonadism is a clinical and biochemical syndrome which may cause significant detriment in the quality of life. With the increase in life expectancy and prostate cancer survival a significant increase in the number of men with hypogonadism who have undergone presumably curative treatment for PCa is anticipated. Despite the widespread contraindication of testosterone in men with known or suspected prostate cancer, there is no convincing evidence that the normalization of testosterone serum levels in men with low, but not castrate levels, is deleterious. Although further studies are necessary before definitive conclusions can be drawn, the available evidence suggests that testosterone replacement therapy can be cautiously considered in selected hypogonadal men treated with curative intent for low risk prostate cancer and without evidence of active disease.

References

Sep 1, 1981·The Journal of Urology·J E Fowler, W F Whitmore
Aug 21, 1996·Journal of the National Cancer Institute·P H GannM J Stampfer
Aug 15, 2001·Urology·G J Bubley
Nov 10, 2001·American Journal of Physiology. Endocrinology and Metabolism·S BhasinT W Storer
Dec 4, 2003·International Journal of Cancer. Journal International Du Cancer·Pär StattinMatti Hakama
Jan 30, 2004·The New England Journal of Medicine·Ernani Luis Rhoden, Abraham Morgentaler
Aug 18, 2004·The Journal of Urology·Joel M Kaufman, R James Graydon
Jan 12, 2005·The Journal of Urology·Piyush K Agarwal, Michael G Oefelein
Sep 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·J Kellogg ParsonsE Jeffrey Metter
Jan 21, 2006·The Journal of Sexual Medicine·Ahmed I El-SakkaHassan A Hassan
Jan 26, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Gianluca SeveriGraham G Giles
May 25, 2006·The Journal of Clinical Endocrinology and Metabolism·Shalender BhasinVictor M Montori
Nov 16, 2006·JAMA : the Journal of the American Medical Association·Leonard S MarksPeter S Nelson
Jun 15, 2007·The Prostate·Sara WirénPär Stattin
Jul 14, 2007·The Journal of Sexual Medicine·Mario MaggiKerstin Uhl-Hochgraeber
Jul 20, 2007·The Journal of Sexual Medicine·Christian J NelsonAndrew J Roth
Jan 31, 2008·Journal of the National Cancer Institute·UNKNOWN Endogenous Hormones and Prostate Cancer Collaborative GroupTimothy J Key
Jul 18, 2008·International Journal of Impotence Research·R ShabsighK M Slawin
Jul 22, 2008·The Journal of Sexual Medicine·Ernani Luis RhodenPatrick E Teloken
Feb 12, 2009·The Journal of Sexual Medicine·Mohit KheraLarry I Lipshultz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Urology Reports
Ernani Luis Rhoden, Márcio Augusto Averbeck
The Journal of Sexual Medicine
Ernani Luis RhodenPatrick E Teloken
Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
A T GuayM Vereb
© 2021 Meta ULC. All rights reserved