Prostate carcinoma patients upstaged by imaging and treated with irradiation. An outcome-based analysis

Cancer
W H PinoverG E Hanks

Abstract

The American Joint Committee on Cancer (AJCC) staging of prostate cancer relies upon digital rectal examination (DRE) findings, but suggests using all available information, including prostate imaging studies, prior to definitive treatment of prostate carcinoma. We have studied whether patients upstaged by imaging have a different outcome after treatment with external beam radiation therapy (RT) from those not upstaged. The records of 499 men with clinically localized adenocarcinoma of the prostate treated with only definitive external beam irradiation from January 1986 to December 1993 were reviewed. The 348 patients with any one or a combination of the following pretreatment imaging studies were considered eligible; transrectal ultrasound (TRUS), pelvic MRI, or endorectal MRI. Patients were assigned two clinical stages: one based upon palpation criteria alone (palpation stage) and the other allowing for any upstaging by imaging abnormalities (AJCC or imaging stage). The Kaplan-Meier method was used to estimate biochemical no evidence of disease (bNED) survival where a failure was defined as a prostate specific antigen (PSA) greater than 1.5 and increasing. Differences in outcome were evaluated by the log-rank test. Overall up...Continue Reading

References

Jan 1, 1977·British Journal of Haematology·J Palek
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·E M SoffenB E Epstein
Sep 1, 1992·Cancer·O H Beahrs
Jan 1, 1991·International Journal of Radiation Oncology, Biology, Physics·E M SoffenJ C Chu
May 15, 1995·International Journal of Radiation Oncology, Biology, Physics·B W CornL R Coia
Feb 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W R LeeM A Hunt
Mar 1, 1995·Radiology·C LanglotzH Pollack
Dec 1, 1993·The American Journal of Surgical Pathology·M OhoriT M Wheeler

❮ Previous
Next ❯

Citations

Dec 30, 1998·International Journal of Radiation Oncology, Biology, Physics·S A SeawardM Roach
Mar 10, 2006·Clinical Oncology : a Journal of the Royal College of Radiologists·F YoonJ Izawa
May 9, 2003·The Urologic Clinics of North America·Alan PollackAlexandra L Hanlon
Jul 30, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Herbert AugustinPeter G Hammerer
Jun 18, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey H BurkhardtJames A Hayman
Apr 8, 1998·International Journal of Radiation Oncology, Biology, Physics·G E HanksM V Pilepich
Jun 19, 2001·International Journal of Cancer. Journal International Du Cancer·T CampbellS Vijayakumar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.